Université de Bourgogne

An Integrated Workflow for Enriched 3D (e3D) Models to Support Conservation Practices in Cultural Heritage: The ChemiNova Project

The project ChemiNova, funded by the Horizon Europe program, is dedicated to the development of an integrated suite of five software modules to enhance the conservation, analysis, and monitoring of cultural heritage assets. Using non-invasive data acquisition technologies, we pro...

Impact of comedication on survival and toxicity in patients treated with systemic therapy for unresectable hepatocellular carcinoma

Introduction This study aims to evaluate the association between concomitant medication, survival and toxicity in patients with unresectable hepatocellular carcinoma (uHCC) treated with systemic therapy. Methods All uHCC patients treated with atezolizumab plus bevacizumab or durv...

Passive ankle exoskeleton assistance selectively modulates triceps surae neural control during balance

Wearable assistive devices have potential to improve human balance, but their effectiveness remains limited by an incomplete understanding of how mechanical assistance influences neuromuscular control. This study aimed to determine the neural adaptations in the control of lower l...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

CD8⁺ T Cell infiltration and spatial organization in cancer: mechanisms, barriers, and therapeutic strategies

Abstract The infiltration of tumors by CD8⁺ T lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy. However, the presence of tumor-specific CD8⁺ T cells does not necessarily translate into effective tumor control, as multiple biological barrie...

The Modality Principle in Immersive and Non‐Immersive Virtual Reality: An Eye Tracking Study

ABSTRACT Background According to the modality principle of the Cognitive Theory of Multimedia Learning, learning is better facilitated when visual content is accompanied by a vocal narration compared to text explanation. However, the application of this principle in immersive vir...

Healthcare professionals’ views on expanding newborn screening with or without genomics in France: Results of the SeDeN-p2 study

Abstract Therapeutic advances and the rapid, cost-effective development of next-generation sequencing (NGS) have increased interest in expanding newborn screening (NBS) through genomics. The SeDeN-p2 study assessed the acceptability among healthcare professionals in France, of ex...

Real‐Time Observation of Soliton Buildup and Self‐Organization in a GHz Harmonic Mode Locked Fiber Laser

ABSTRACT Ultrafast fiber lasers operating at GHz repetition rates are critical for applications requiring high‐speed optical pulse sources. To achieve such rates, passive harmonic mode locking (HML) constitutes a logical pathway, whose practical implementation is hampered by the...

End-of-induction circulating tumor DNA outperforms conventional cellular MRD for predicting early progression in follicular lymphoma: an ancillary study of the RELEVANCE randomized trial

In this ancillary study of the RELEVANCE phase III trial (NCT01650701), we performed the first direct intra-patient comparison of circulating tumor DNA (ctDNA)-based versus cellular t( BCL2 / JH ) translocation-based MRD at end of induction (EOI) in 278 patients with advanced FL,...

Adolescent elite swimmers’ self-esteem and emotional states: Benefits of organized leisure-time activities

This study examined whether an Organized Leisure-Time Activities program (OLT3A) strengthens self-esteem and emotional states in elite adolescent swimmers. Twenty-five national-level swimmers (Mage = 14.44 ± 1.23 y) were randomized to a six-week OLT3A intervention or a waiting-li...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Efficacy of a digital mental health program for university students: A randomized controlled trial comparing online and hybrid delivery

University students are a high-risk population for mental health problems. However they often face barriers to care. Digital Mental Health Interventions are scalable tools to support well-being, yet evidence regarding optimal delivery formats remains mixed. This study assessed th...

Trust, intangible assets, and productivity

Abstract Business environments dominated by information flows and autonomous tasks, typical of knowledge‐intensive industries, are likely to require enough social trust to be viable and productive. In this paper, we use new EUKLEMS & INTANProd industry‐level data covering a panel...

Infinite simple characteristic quotients

We construct continuum many infinite, simple, characteristic quotients of non-abelian free groups, answering a 1978 question of James Wiegold. The method is very flexible, allowing to impose certain properties on the quotients, to generalize the construction to large classes of g...

Effects of Maximal Concentric Contractions on Myotendinous Mechanical Properties in Prepubertal Boys

ABSTRACT This study aimed to compare the effects of a fatiguing concentric exercise on the myotendinous mechanical properties of the knee extensors between men and prepubertal boys. Ten prepubertal boys and 10 men performed a fatiguing exercise consisting of five sets of 20 maxim...

Cultural bias or universal traits? Exploring personality-like profiles of large language models

Abstract Do large language models (LLMs) exhibit coherent personality profiles, and are these profiles culturally neutral? This study used two validated personality inventories, the Big Five Inventory–2 and the Dark Triad Dirty Dozen, to assess five state-of-the-art LLMs (ChatGPT...

Near-Infrared Organic Structures with Extended Lifetimes to Unlock the Potential of In Vivo Fluorescence Lifetime Imaging

Abstract In vivo fluorescence lifetime imaging (FLI) is an advanced optical imaging modality with the capability to reveal additional biological information compared to fluorescence intensity (FI) imaging. In addition to enabling tissue discrimination based on microenvironmental...

Understanding rhythmic behavior in infancy: Perspectives for addressing developmental, methodological, and analytical challenges

Neural sensitivity to rhythm emerges prenatally, yet observable movement synchronization to an external beat occurs later and more gradually over development. Integrating findings from developmental psychology, neuroscience, music cognition, and social interaction research, we pr...

Fewer players, bigger opportunity: How structural rule modifications shape physical and technical demands in youth rugby union

Purpose Youth rugby governing bodies have progressively revised competition formats to align game demands with children's developmental characteristics. However, empirical evidence remains limited on whether these structural modifications increase children's locomotor and technic...

Titanium‐Catalyzed Defluorination of Poly(Vinyl Fluoride) and Poly(Vinylidene Fluoride) Under Friedel–Crafts Conditions

ABSTRACT The defluorination of poly(vinyl fluoride) (PVF) and poly(vinylidene fluoride) (PVDF) fluoropolymers catalyzed by titanium species in the presence of triethylsilane (Et 3 SiH) and aromatic solvents is reported. Commercially available Ti complexes (e.g., [Cp 2 TiCl 2 ] (...