Institution
Universitätsmedizin Greifswald
Recent research
- Society & EconomicsOpen access
Abstract Background Caregiving for children with rare diseases is associated with substantial psychosocial and practical burden, yet evidence on associated factors of caregiver burden across heterogeneous rare disease populations remains limited. Methods In this cross-sectional s...
- Health & MedicineOpen access
Abstract Dysregulated αvβ3 integrin activation in podocytes contributes to proteinuric kidney disease by disrupting podocyte architecture and the glomerular filtration barrier. However, no treatments currently exist that therapeutically target this integrin. We previously identif...
- Health & MedicineOpen access
Abstract Background Torque control of anterior teeth remains a major challenge in clear aligner therapy. Power ridges have been introduced to improve buccolingual root control; however, their biomechanical performance in directly printed aligners remains insufficiently investigat...
- Health & MedicineOpen access
Identification of infection in critically ill patients remains challenging, as conventional biomarkers such as C-reactive protein (CRP), procalcitonin (PCT) and white blood cell count (WBC) frequently lack diagnostic accuracy. The Intensive Care Infection Score (ICIS), a host-res...
- BiologyOpen access
Background The phenotypic plasticity of vascular smooth muscle cells (VSMCs) can modulate atherosclerosis progression. Although several gene regulatory steps towards pro-inflammatory phenotypes have been well-studied, epitranscriptomic changes during this transition and their reg...
- Health & Medicine
Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...
- Society & EconomicsOpen access
BACKGROUND: When a parent is diagnosed with cancer, it can place a significant burden on the entire family. The aim of this study is therefore to analyse the psychological distress experienced over time among cancer patients or their partners who are raising minor children and wh...
- BiologyOpen access
Next-generation functional foods provide a paradigm shift from generalized healthcare to personalized nutrition. Rational design of functional ingredients based on structure-activity relationships is essential for their further development. Because of high substrate specificity a...
- Health & MedicineOpen access
Abstract Background Dyslipidaemia remains a leading cause of death in Germany despite an improving therapeutic landscape, with many patients not achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals. Bempedoic acid, an adenosine triphosphate citrate ly...
- Engineering & TechnologyOpen access
Abstract Objectives Photon-counting CT (PCCT) enables dose reduction beyond energy-integrating CT, but ultra-low-dose acquisitions may impair assessment of airways and lung parenchyma. We evaluated the impact of ultra-low-dose (ULD) PCCT on quantitative and qualitative lung param...
- Health & MedicineOpen access
Abstract Background Multiple myeloma (MM) is a widely incurable B-cell malignancy that predominantly affects older adults, representing 10% of hematologic cancers. Despite advancements in therapy that have significantly extended median overall survival (OS), MM remains a clinical...
- Climate & EnvironmentOpen access
Stratospheric aerosol injections (SAI) have been proposed as a potential climate intervention to mitigate some effects of global warming. This method involves the idea of injecting sulphur dioxide into the stratosphere. Other ideas include the injection of solid particles, like a...
- Society & EconomicsOpen access
Abstract Career choice motives play a central role in teacher development, professional commitment and retention. Although special education is often assumed to attract individuals with strong pedagogical and altruistic motives and lower extrinsic orientations, empirical evidence...
- Health & MedicineOpen access
Abstract Background Obesity is associated with altered immune function and may therefore influence the response to influenza vaccination. So, the objective was to investigate whether body mass index (BMI) affected influenza-specific antibody titers and immune cell counts after va...
- Society & EconomicsOpen access
Abstract: Although extensive research has examined the link between subjective aging (i.e., individuals’ subjective age and their self-perceptions of aging) and health-related outcomes, little is known about the role of specific chronic diseases in shaping long-term trajectories...
- Engineering & TechnologyOpen access
Short-read genome skimming enables molecular barcoding of old myxomycete collections
This study evaluates the effectiveness of Illumina-based genome skimming for barcoding myxomycete herbarium collections ranging from 29 to 91 years in age. We successfully retrieved partial sequences of the standard marker gene (nucSSU) in all cases, as well as additional markers...
- Health & Medicine
Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation
BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...
- Health & MedicineOpen access
Abstract Background Effective care of people with cognitive impairment and their families depends, among other things, on the cooperation of the professionals involved in their care. An effective dementia care management support model for people with dementia and their families f...
- BiologyOpen access
Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort
Abstract Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratified normative...
- Health & MedicineOpen access
Background: Iodine is an essential micronutrient required for foetal development, cognitive function, and metabolic regulation; however, suboptimal iodine status remains a public health concern in Europe and other regions. Improving food literacy related to iodine may support hea...