Universitätsmedizin Greifswald

Short-read genome skimming enables molecular barcoding of old myxomycete collections

This study evaluates the effectiveness of Illumina-based genome skimming for barcoding myxomycete herbarium collections ranging from 29 to 91 years in age. We successfully retrieved partial sequences of the standard marker gene (nucSSU) in all cases, as well as additional markers...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort

Abstract Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratified normative...

Process evaluation of the randomized trial—“Care management for older people with cognitive impairment during and after hospitalisation in Germany (intersec-CM)”

Abstract Background Effective care of people with cognitive impairment and their families depends, among other things, on the cooperation of the professionals involved in their care. An effective dementia care management support model for people with dementia and their families f...

Designing a School-Based, Complex Public Health Intervention to Improve Iodine Awareness in Adolescents in Six Countries

Background: Iodine is an essential micronutrient required for foetal development, cognitive function, and metabolic regulation; however, suboptimal iodine status remains a public health concern in Europe and other regions. Improving food literacy related to iodine may support hea...

Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP)

Abstract Background Hearing loss has been reported as a major, potentially modifiable risk factor for dementia and often co-occurs with tinnitus. Both conditions are prevalent and have been linked to brain health and cognitive decline. However, evidence from studies containing th...

miR-155-5p drives coordinated tumor and macrophage reprogramming across multiple cancer entities

Abstract Background T cell-based immunotherapies have improved cancer treatment, however their efficacy is frequently limited by tumor-intrinsic resistance mechanisms and by the immune suppressive tumor microenvironment, counteracting tumor specific immune responses through impai...

Transcranial Electrical Stimulation and Delirium Among Postoperative Patients

Importance Postoperative delirium (POD) occurs as a significant complication after elective surgery. Objective To investigate the modulation of delirium incidence by transcranial electric stimulation (tES). Design, Setting, and Participants A double-blind, sham-controlled randomi...

Quantum approximate optimization algorithm with fixed number of parameters

We introduce a novel quantum optimization paradigm: the Fixed-Parameter-Count Quantum Approximate Optimization Algorithm (FPC-QAOA). It is a scalable variational framework that maintains a constant number of trainable parameters regardless of the number of qubits, Hamiltonian com...

A Systematic Review and Meta-Analysis on 30-Day Readmission Rates After Endovascular Abdominal Aortic Aneurysm Repair and Open Repair

AIM: Endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) are established treatments for abdominal aortic aneurysm (AAA). This meta-analysis evaluated 30-day readmission, patient characteristics, postoperative complications, and length of stay after EVAR and OAR, an...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Webinars about child and adolescent psychiatry can support professionals in war-affected regions: lessons from the ESCAP-Ukraine webinar initiative

War has a profound impact on child and adolescent mental health and service provision. This requires creative internationally supported response to strengthen professional capacity in trauma care, psychosocial support and evidence based clinical practice in child and adolescent p...

Neurovascular compression of the left rostral ventrolateral medulla is not associated with arterial hypertension in a population-based MRI study in Germany

PURPOSE: Neurovascular compression (NVC) of the rostral ventrolateral medulla (RVLM) is discussed as a cause for arterial hypertension (aHT). This study aimed to investigate the prevalence and the extent of NVC of the RVLM and to evaluate association with aHT in Germany. METHODS:...