Universitätsklinikum Gießen und Marburg

Are childhood diseases associated with Molar-Incisor Hypomineralization? – Results from an observational study

Abstract Objective This observational study aimed to investigate the potential association between reported childhood diseases and medications during early infancy and the later appearance of molar incisor hypomineralization (MIH). Materials and methods As part of a prospectively...

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E6...

Cadaveric training of total hepatic vascular exclusion for juxtahepatic venous injury: a technical study

Abstract Purpose Retrohepatic inferior vena cava (IVC) injury is a rare but frequently fatal challenge in trauma surgery. This study describes a structured cadaveric training sequence for total hepatic vascular exclusion (THVE), including transdiaphragmatic intrapericardial IVC e...

Outcome‐Guided Immunosuppressive Therapy and Clinical Events in Patients With Cardiac Sarcoidosis: An Observational Registry

Background Immunosuppressive therapy (IST) is commonly used in cardiac sarcoidosis, but the strategy to guide it is unclear and its effectiveness uncertain. We assessed the association between IST, guided by clinical course and positron emission tomography, and clinical outcomes...

The Pear Strategy for Two‐Ring Pulmonary Vein Isolation: Antral and Sleeve Ablation Using a Balloon‐in‐Basket Pulsed Field Ablation Catheter

ABSTRACT Background Pulsed field ablation (PFA) has emerged as a promising energy source for atrial fibrillation (AF) catheter ablation. This study aimed to describe the adoption and workflow optimization of a novel balloon‐in‐basket PFA catheter using a two rings balloon and pea...

Clinical outcomes and toxicity of electron-based intraoperative radiotherapy for partial breast irradiation: a single-institution experience

Purpose: Partial breast irradiation (PBI) using intraoperative electron radiotherapy (IOeRT) represents an attractive alternative to whole-breast irradiation in carefully selected patients with early breast cancer. Materials and Methods: Eighty-nine patients treated with single-d...

Hospital Length of Stay and Associated Factors in Patients with Oral Cavity Cancer in Germany: A Retrospective Multicenter Analysis of Inpatient Administrative Data

Background: Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resource use and complexity of care,...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes

Although temporal information is ubiquitous in natural vision, the cortex shows strong intrinsic rhythmicity. Recent electroencephalogram (EEG) studies have revealed a component of the visual impulse response function (IRF) resembling a narrow alpha-band (7–13 Hz) filter with a s...

Optimal timing of post-therapeutic [131I]NaI whole-body scintigraphy in predominantly low- and intermediate-risk differentiated thyroid cancer: a secondary analysis of prospectively acquired data and a structured literature review

Abstract Background Post-therapeutic [ 131 I]NaI whole-body scintigraphy (ptWBS) is mandatory after radioiodine therapy (RAIT), but the most suitable acquisition time remains uncertain. We compared image interpretability at early and delayed time points in patients with different...