Universitätsklinikum Erlangen

Coxiella burnetii establishes a small cell variant (SCV)-like persistent form to survive adverse intracellular conditions

Abstract Coxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Infections can be either acute or chronic. Of note, chronic Q fever develops months or years after primary infection without clinical symptoms, suggesting bacterial persistence. Yet, i...

Organ and tumor dosimetry of [161Tb]Tb-PSMA-617 radioligand therapy in patients with mCRPC

Abstract Purpose Terbium-161 ( 161 Tb) has emerged as a promising radionuclide for radioligand therapy (RLT) due to its emission of Auger and conversion electrons, which may support therapeutic efficacy through increased local energy deposition. Despite growing research efforts a...

Fully automated pipeline for localization and scoring of rheumatic disease related regions and pathologies in hand MRI

Rheumatic diseases constitute a major cause of chronic pain, functional impairment, and long-term disability worldwide. In rheumatic diseases, reliable assessment of structural damage and inflammatory activity is essential for diagnosis, disease monitoring, and treatment response...

OpenMRF : A Modular, Vendor‐Neutral Open‐Source Framework for Magnetic Resonance Fingerprinting Using Pulseq

ABSTRACT Purpose Widespread adoption and methodological advancement of magnetic resonance fingerprinting (MRF) are limited by the lack of unified, reproducible implementation frameworks and fragmented open‐source tools. To address these barriers, we introduce OpenMRF—a comprehens...

Association between macular edema area on optical coherence tomography and Amsler grid sensitivity in diabetic macular edema: a cross-sectional study

Abstract Background Early detection of diabetic macular edema (DME) is essential to prevent vision loss through timely treatment. Optical coherence tomography (OCT) is the diagnostic gold standard but is not suitable for home monitoring. The Amsler grid represents a simple and in...

How reliable is deep inspiration breath hold at CT simulation? Clinical impact of surface-guided breathing training in breast cancer radiotherapy

Abstract Purpose Deep inspiration breath hold (DIBH) is widely used to reduce cardiac dose in left-sided breast radiotherapy. However, the reliability of DIBH at CT simulation, has not been systematically evaluated despite the importance of CT simulation as the basis for treatmen...

Difficult-to-treat systemic lupus erythematosus: from refractory disease to a multidimensional clinical trajectory

Difficult-to-treat (D2T) systemic lupus erythematosus (SLE) is increasingly recognised in clinical practice but is still conceptually underdeveloped. In contrast to rheumatoid arthritis and psoriatic arthritis, for which formal D2T frameworks have been proposed, SLE still lacks a...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

The interaction between the ERG responses to sinusoidal modulation and flashes in mice

Abstract Purpose To study the interaction between responses to a sinusoidal modulation and a flash in the mouse ERG. Methods We recorded responses to pulses on a 1 Hz sinewave background (Pulse on Sine Stimuli: PoS) in mice. Flashes were presented at 8 different temporal phases r...

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020–2022

Abstract Patients with malignant lymphomas are at increased risk for severe COVID-19. In the general population, outcomes of COVID-19 have improved dramatically over time due to increasing immunity through vaccination or infection and due to improved clinical care. It is unclear...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

High-resolution peripheral quantitative computed tomography imaging and bone biomarker characteristics of patients with ischemic stroke or transient ischemic attack—baseline analysis of the Post-stroke Osteopathy study

Stroke or transient ischemic attack (TIA) leads to unfavorable structural changes in the bones. The underlying pathophysiological process is unclear. We provide a detailed characterization of the structural and biochemical properties of bone in a stroke/TIA cohort. Our findings l...

Efficacy and safety of SP16 in preventing acute kidney injury in at-risk subjects with chronic kidney disease undergoing elective cardiac surgery using the heart–lung-machine (EASE-AKI): study protocol for a prospective, randomised, double-blind, placebo-controlled clinical trial

Abstract Background Cardiac surgery using cardiopulmonary bypass uses controlled hypoperfusion which leads to relative organ damage. Acute kidney injury is the most frequent and most important organ failure, in particular in patients with chronic kidney disease. To date, there ar...

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

Pediatric Clostridium septicum infections: a systematic review and case-based perspective

Abstract Context Pediatric Clostridium septicum infections are extremely rare but often fulminant and rapidly progressive. They may manifest as clostridial myonecrosis, sepsis, or with gastrointestinal involvement. Systematic data on presentation, management, and outcomes remain...

Knowledge and Risk Perception Regarding Skin Cancer in Immunosuppressed Patients: A Systematic Review and Meta-Analysis

Immunosuppressed patients have a substantially increased risk for developing skin cancer. Therefore, it is mandatory that such patients are adequately informed and aware of skin cancer and their increased risk to modify their behavior. Numerous studies have evaluated the topic, b...

First-line immune checkpoint inhibitors versus chemotherapy in delaying quality of life deterioration in advanced NSCLC: a systematic review and meta-analysis

Backgroud: Immune checkpoint inhibitors (ICIs) have transformed first-line treatment for advanced non–small-cell lung cancer (aNSCLC). While overall survival(OS) remains the primary endpoint, health-related quality of life (HRQoL) is a key patient-centered outcome. Time to deteri...

Adapted foundation models for breast MRI triaging in contrast-enhanced and non-contrast-enhanced protocols

Abstract Objectives To evaluate a DINOv2-based medical slice transformer (MST) for triaging abbreviated breast MRI by ruling out examinations with suspicious findings that are immediately actionable (Breast Imaging Reporting and Data System [BI-RADS] ≥ 4) across contrast-enhanced...

Shifting AAV9 tropism by binding moiety insertion enhances transduction of tumor cell lines and human glioblastoma explants

Abstract Tumor-specific targeting remains a major obstacle for the development of precision cancer therapies. For several tumors and specifically glioblastoma (GBM), an aggressive brain tumor with poor prognosis, more effective treatments are urgently needed. Recombinant adeno-as...

Effects of hyperbaric oxygen therapy on human musculoskeletal pathologies in clinical studies: a systematic review

Abstract Background Hyperbaric oxygen therapy (HBOT) has gained increasing interest in regenerative medicine for its capacity to enhance tissue oxygenation, reduce inflammation, and accelerate healing. While its use in musculoskeletal medicine is expanding, particularly among ath...