Universitätsklinik Balgrist

Effects of secondary factor VIII prophylaxis on joint and bone health in a hemophilia A mouse model

Not available.

PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx‐Lineage Cells Accelerates Structural and Functional Recovery

ABSTRACT Previous work has identified PIEZO1 as an important mechanosensor in homeostatic tendon, where it detects mechanical overload and regulates tissue adaptation. Here, we investigated the consequences of PIEZO1 depletion during tendon healing using a full‐thickness central‐...

Decomposing diagnostic criteria in neurology: a scoping review of components and structure to inform criteria development

Abstract Background Diagnostic criteria are critical for the accurate diagnosis of neurological diseases, which are among the most challenging to define. They help to standardize global efforts in healthcare delivery and scientific investigation. Despite their importance, no stan...

Outcome of lumbar fusion with template-guided cortical bone trajectory versus traditional pedicle screw trajectory – a prospective randomized trial

Abstract Purpose Traditional trajectory (TT) pedicle screw fixation remains the reference standard for lumbar fusion. Cortical bone trajectory (CBT) screw placement has been proposed as a less invasive alternative with potential biomechanical advantages, but the technique is dema...

Reward reduces motor fatigability by increasing movement vigour

Abstract Reward can enhance motor performance. However, its potential to counteract motor fatigability, a reduction in motor performance during sustained movements, remains underinvestigated. This could be relevant in neurological conditions such as multiple sclerosis, where incr...

Quantification of Incomplete A2 Pulley Ruptures and the Question of Coexistent A3 Pulley Ruptures in Sport Climbers

Objectives To quantify the extent of A2 pulley ruptures and the presence of a potential coexistent A3 pulley rupture in sport climbers. Methods Prospectively and consecutively acquired patients presenting to Balgrist University hospital with an A2 pulley rupture due to sport clim...

Reinforced Polyester Patch Augmentation Improves Biomechanical Properties of Thin Fascia Lata Grafts for Superior Capsule Reconstruction

Purpose To investigate the effect of reinforced polyester patch augmentation on the biomechanical characteristics of thin fascia lata graft. Methods Three graft types were made from fascia lata: (1) thin graft; (2) thin graft augmented with a reinforced polyester patch placed bet...

Select large language models outperform hip preservation experts on consensus‐based hip preservation questionnaire

Abstract Purpose Artificial intelligence (AI) is increasingly utilized in medical education and clinical contexts, yet few studies compare the performance of large language models (LLMs) to subspecialized experts in providing guideline‐based medical information on hip preservatio...

Impact of Structured Data Validation on Case Completeness and Key Quality Indicators in the SWISS Implant Registry (SIRIS Spine): A SINGLE-CENTER Audit

Study design Retrospective single-center registry validation audit. Objective To quantify the impact of semi-automated, chart-adjudicated data validation workflow on case completeness and key quality indicators in the Swiss Implant Registry (SIRIS Spine). Methods All Swiss proced...

Prospective annual evaluation of sports motor performance, BMI and social index in Swiss first graders over a period of 12 years

Abstract Understanding factors that influence children’s motor development is of major public health relevance, given its association with physical activity, health trajectories, and long-term well-being. This study evaluates neuromotor development alongside environmental factors...

Short- to mid-term clinical outcomes and return to sport and work after arthroscopic debridement of the extensor carpi radialis brevis in patients with chronic lateral epicondylopathy

BACKGROUND: This study aimed to evaluate the short- to mid-term clinical outcomes following arthroscopic extensor carpi radialis brevis (ECRB) debridement in patients with chronic epicondylopathy humeri radialis (cEHR). We hypothesized that arthroscopic ECRB debridement would res...