Universitäts-Herzzentrum Freiburg-Bad Krozingen

The functional impact of myofiber macroscopic organization and disarray in computational models of the murine heart

A major challenge in computational models of cardiac electromechanics is the reconstruction of myocardial fiber architecture, as direct in vivo measurements of fiber orientation are not feasible. Consequently, rule-based methods are commonly adopted as surrogates, relying on empi...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Understanding-Aligned Intelligence Framework (UAIF): Which Parts of This Architecture Survive Cognitive Parity

Version 1.0.0 of this framework, published in January 2026, proposed a five-layer architecture for aligning an artificial system. At its base is a constitution derived from international human rights law. Above it sit a proof validator that checks certificates instead of searchin...

Invariance Without a Beneficiary: What Survives Cognitive Parity, and on What Grounds

Past the parity threshold this corpus has closed route after route, and read quickly the series says that nothing holds. It does not say that. Every closed route was a configuration whose working condition contained a relative capacity term, and the complementary question was nev...

Enforcement Without Overmatch: What Survives of Economic Standing after Cognitive Parity

Past the parity threshold, the framework this paper belongs to has priced every route it examined by which a weaker party might still direct a stronger system, and each closed at the same joint. One adjacent route was reserved, not examined: the legally constituted duty, describe...

Subgroup variations in effectiveness of femoropopliteal sirolimus versus paclitaxel-coated balloon angioplasty: post hoc results of the randomised SIRONA trial

INTRODUCTION: The randomised SIRONA trial showed that sirolimus-coated balloon (SCB) angioplasty was non-inferior to paclitaxel-coated balloon angioplasty (PCB) regarding femoropopliteal primary patency. There was no difference in clinically driven target lesion revascularisation...

Sirolimus-eluting balloon for the treatment of peripheral artery disease: SUCCESS PTA real-world single-arm study

BACKGROUND: Outcomes with sirolimus-coated drug-eluting balloons (DEB) have been positive for the treatment of femoropopliteal arterial lesions but have not been studied in a broader patient population. OBJECTIVES: Collect real-world safety and effectiveness data on the SELUTION...

Soundness Without Leverage: What Survives of Verification after Parity

Beyond the parity threshold, the framework this paper belongs to has closed the channels through which a weaker party might still direct a stronger system. Containment dissolves, deference expires, no uptake form holds between evidence and standing, and the coupling's normative a...