Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Radiographic Evaluation of Scoliosis in Pediatric, Adolescent, and Young Adult Patients: Associations Between Curve Severity, Localization, and Skeletal Maturity

Background/Objectives: The vertebral column is exposed to significant mechanical loads, exceeding 8000 N at certain levels due to bipedal posture and locomotion. These forces may contribute to structural alterations during growth. Scoliosis is among the most common structural spi...

Exploratory Associations of Subjective Sleep Characteristics, Psychosocial Factors, and Glycemic Control in Adults with Type 1 Diabetes

Background/Objectives: Sleep health contributes to glucose homeostasis and metabolic regulation. We explored associations between subjective sleep characteristics, glycemic control, and diabetes-related clinical factors in adults with type 1 diabetes mellitus (T1DM). Methods: Thi...

Effect of Cyclodextrin Complexation on the Separation of Insulin Analogues in Capillary Electrophoresis Using Dynamically Coated Capillaries

The simultaneous separation of therapeutic insulin analogues by capillary electrophoresis (CE) remains challenging because of their high structural similarity and their tendency to adsorb onto the capillary surface. This study investigated the applicability of cyclodextrin (CD) d...

Locked in, Left Behind: Clinical, Psychosocial, and Ethical Dimensions of Prison Health—A Narrative Review

The global prison population has expanded over recent decades, straining correctional systems and positioning detention facilities as critical, yet frequently overlooked, sites of health inequity. With an estimated 11.5 million people currently incarcerated worldwide, prisons hav...

Advanced Carcinoid Tricuspid Valve Disease Associated with Delayed Recognition and Loss of the Interventional Window in a Patient with Ileal Neuroendocrine Tumor: A Case Report

Background and Clinical Significance: Carcinoid heart disease remains one of the most serious complications of carcinoid syndrome, yet cardiac involvement may still be recognized late, when valvular damage is already advanced and treatment options are limited. Case Presentation:...

Malignancies in horseshoe kidneys: an updated review

Out of over 4000 available studies about horseshoe kidney (HSK), we selected 89 representative articles that emphasized the most common genetic lesions and tumors that can occur in these patients. Renal cell carcinomas, carcinomas of the urothelial tract, and Wilms tumor are the...

Myocardial Injury and Predictors of In-Hospital Mortality in Severe or Critical COVID-19: A Single-Center Observational Cohort Study

Background and Objectives: In-hospital mortality remains high among patients with severe or critical COVID-19. This study aimed to identify independent predictors of in-hospital mortality and assess the prognostic value of myocardial injury in this high-risk population. Materials...

Preparation and Characterization of Fenofibric Acid-Loaded Electrospun Fibrous Mats

Fenofibric acid-loaded microfibrous mats were produced by electrospinning using polyvinylpyrrolidone (PVP) as a carrier polymer. Fenofibric acid, obtained through alkaline hydrolysis of fenofibrate, was incorporated into PVP solutions and processed under optimized electrospinning...

Early Nutritional–Immune Biomarker Trajectories Following Gastrectomy for Gastric Cancer: A Prospective Longitudinal Cohort Study

Background: Nutritional deterioration is a common consequence of gastrectomy for gastric cancer and may persist despite standardized perioperative care. However, prospective longitudinal evidence describing the early course of postoperative nutritional recovery remains limited. T...

What Is Stressful About Medical Liability? A Retrospective Jurisprudential Analysis of Moral Damages and Discussions on Its Impact on Healthcare Professionals’ Well-Being

Background/Objectives: Medical liability litigation in Romania has risen steadily over the past decade, yet the quantification of moral (non-pecuniary) damages remains entirely at the discretion of each judge, with no standardized reference. This raises concerns about consistency...

Clinical Utility of Dual-Energy CT for Detection, Characterization, and Staging of Lung Tumors: A Rapid Review

Background/Objectives: Lung cancer remains one of the leading causes of cancer-related mortality worldwide. Conventional computed tomography (CT) is the preferred imaging modality for evaluating pulmonary nodules because of its high spatial resolution; however, it primarily provi...

Systems Bioengineering of Septic Shock Metabolism: Citrulline, β-Hydroxybutyrate and Plasma Biomarker-Based Phenotyping

Background: Although advances in critical care have improved short-term outcomes, sepsis survivors continue to face substantial chronic morbidity and impaired long-term survival. Conventional threshold-based tools such as the Sequential Organ Failure Assessment (SOFA) and Modifie...

The Role of Pyrrolidine in Antibacterial Drug Discovery: Clinically Approved Antibiotics, Novel Derivatives, and Future Perspectives

Antimicrobial resistance is a major global health challenge that has created an urgent need for new antibacterial agents capable of overcoming emerging resistance mechanisms. Among nitrogen-containing heterocycles, pyrrolidine has been widely investigated in medicinal chemistry d...

The Cost of the Cure: Antibiotic Exposure as a Risk Factor for Irritable Bowel Syndrome

The intricate interplay between the gut microbiome and the enteric nervous system remains a paramount focus in understanding the multifactorial pathogenesis of disorders of gut–brain interaction (DGBI), most notably irritable bowel syndrome (IBS). While the clinical entity of pos...

A New Cosmeceutical Approach for Mature Skin: Antioxidant Activity, In Vitro Permeation, and Preliminary Clinical Efficacy of Melatonin–N-Acetylcysteine Creams

Skin ageing is associated with oxidative stress, mitochondrial dysfunction, extracellular matrix alterations, and impaired barrier function, supporting interest in antioxidant cosmeceuticals for mature skin. This study investigated the antioxidant activity of melatonin and N-acet...

Integrated Analysis of Zinc, Copper, and Magnesium Homeostasis in Pediatric Idiopathic Nephrotic Syndrome: A Prospective Cohort Study with Serial Clinical Evaluation

Background: Idiopathic nephrotic syndrome (NS) in children is characterized by urinary protein loss and potential disruptions in trace element homeostasis. The dynamic changes in zinc, copper, and magnesium levels in relation to disease activity remain incompletely defined. Objec...

Emotional Stability and Emotional Eating in Medical Students: Exploring Indirect Associations Involving Anxiety and Depressive Symptoms

Background/Objectives: Emotional stability is a personality trait associated with emotion regulation and adaptation to stress. Low emotional stability has been associated with anxiety, depressive symptoms, and emotional eating, but the mechanisms underlying these relationships am...

Clinician-Guided Deep Learning Segmentation of Skull Base Pneumatization on Computed Tomography Using 3D Slicer and MONAI Label

Skull base pneumatization is anatomically variable and clinically relevant to temporal bone and transsphenoidal surgical corridors, but manual volumetric segmentation is time-consuming. This retrospective pilot study evaluated a clinician-guided deep learning workflow for mastoid...