Universität Trier

eDNA metabarcoding provides scalable and continuous biodiversity monitoring across the tree of life

Abstract Environmental DNA (eDNA) metabarcoding has the potential to substantially expand our knowledge of global biodiversity beyond that provided by conventional approaches. However, the degree to which eDNA data provides real ecological insight, rather than primarily reflectin...

Crossing experiments suggest a simple genetic basis of complex male self-sacrifice phenotypes in widow spiders

Abstract Sexual cannibalism is among the most extreme outcomes of sexual conflict, and the Australian widow spider Latrodectus hasselti is well known for this behaviour. Curiously, males of L. hasselti actively facilitate cannibalism through self-sacrificial mating traits. During...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...