Universitat de Vic - Universitat Central de Catalunya

Design and validation of a GMP-compliant manufacturing platform of extracellular vesicles from mesenchymal stromal cells

There is growing interest in mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) as key components in the development of next-generation regenerative cell-free therapies; however, their clinical translation remains limited by a lack of validated clinical-grade manuf...

Enhancing learning health care systems with real-world data harmonization frameworks

The use of digital tools has enabled the capture of clinical data that can be leveraged to produce real-world evidence, complementing traditional trial data and addressing evidence gaps in oncology. Electronic health records offer rich, longitudinal data, although recording pract...

Implementation of a Multidisciplinary Non‐Pharmacological Program to Improve Urinary Incontinence in an Intermediate Care Hospital

ABSTRACT Introduction Urinary incontinence (UI) is a prevalent geriatric syndrome that significantly affects the physical, psychological, and social well‐being of older adults. Non‐pharmacological interventions are recommended as the first‐line approach, especially in frail older...

Sustainable Building in Catalonia: Recycling, Energy Efficiency and the Circular Economy in Construction

This study analyses how the construction sector in Catalonia is advancing towards a circular economy model through four dimensions: construction and demolition waste (CDW) recycling, Energy Saving Certificates (CAEs), passive building design and the RECONS environmental certifica...

Surface roughness-driven inverse design of milling processes using machine learning

Interest in applying data-driven approaches in manufacturing has grown significantly, particularly for mapping complex, high-dimensional relationships. The milling process is one area where predictive models can link influential parameters to surface roughness metrics prior to in...

Precise resistance training alleviates osteosarcopenia via the GLP-1/myostatin path: a 32-week randomized controlled trial and molecular mechanism study

Background: With the ageing of the global population, osteoporosis poses a serious challenge to elderly health. Purpose: The aim is to explore the intervention effect and molecular mechanism of resistance training (RT) based on precise mechanical load monitoring on patients with...

Circulating tumor DNA-guided de-escalation or escalation of adjuvant therapy in high-risk stage II and stage III colon cancer: the phase 2 PEGASUS trial

Oxaliplatin–fluoropyrimidine combinations are standard adjuvant therapy after radical resection of high-risk stage II and stage III colon cancer but expose many patients to toxicity while failing to prevent relapse in others. PEGASUS was a multicenter, single-arm, phase 2 trial e...

Effects of Polyaromatic Film Interfaces on Cu Catalysts for Selective Electrochemical CO2 Reduction

Abstract Electrochemical CO2 reduction (CO2RR) offers a sustainable pathway to convert CO2 into energy-dense fuels and value-added chemicals, addressing both climate and energy storage challenges. This study investigates the effect of polyaromatic film (PAF) coatings on Cu-based...

Shedding light on the formation mechanisms of Islamic polychrome lusters: A Cu, Fe, Ag micro XANES study

Islamic luster is a ceramic glaze decoration exploiting the quantum-confined optical response of noble metallic nanoparticles to produce a colorful metallic and iridescent appearance. Upon firing, silver and copper initially present in an overpaint diffuse into the glaze and are...

A cluster-randomized controlled trial of a family-based psychosocial intervention to prevent childhood obesity from preschool ages: the PRESAFALIN study protocol

Abstract Background: Childhood obesity is a major global concern, and Spain's high obesity rates highlight the urgent need for effective and innovative interventions in early age. The PRESAFALIN study aims to promote parental competence, self-efficacy, and resilience to improve c...

Comprehensive proteomic profiling of platelet-rich plasma from elderly individuals: insights for autologous therapeutic applications

Autologous platelet-rich plasma (PRP) is commonly used to enhance tissue repair. Its effectiveness may be limited by the patient’s individual condition. Given that aging impacts tissue regeneration, it is important to analyze the composition of the PRP obtained from elderly indiv...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Co-creating an intergenerational intervention to enhance physical activity in the older adult population: A qualitative study of the engAGE project

Background Older adults are the most sedentary population segment, and effective, sustainable interventions are needed to modify these behaviours. Intergenerational and participatory approaches may enhance adherence and support long-term engagement. This study reports on the co-c...

Mapping autonomy in mental health care: a scoping review protocol

Autonomy is regarded as a fundamental principle in the global reform of mental health care, as promoted by the Convention on the Rights of Persons with Disabilities (CRPD) and reflected in various international initiatives aimed at eliminating coercive practices and fostering rig...

Key recommendations for primary care from the 2026 GOLD update

The Global Initiative for Obstructive Lung Disease (GOLD) has produced yearly recommendations for the diagnosis and management of patients with COPD since 2001. Here, we summarize the key recommendations of the GOLD 2026 document for a primary care audience, highlighting what has...

Diagnostic Accuracy of Rectus Femoris Ultrasound for Identifying Sarcopenia as Defined by the European Working Group on Sarcopenia in Older People 2 in Haemodialysis Patients

Background: Sarcopenia is highly prevalent in patients with end-stage renal disease and is associated with adverse outcomes. We evaluated the diagnostic accuracy of rectus femoris ultrasound, compared with bioimpedance spectroscopy (BIS), for identifying sarcopenia defined by the...

Exploring Nursing Team Perceptions of Sleep in Critically Ill Pediatric Patients: A Mixed-Methods Study

Objective: To explore nursing team perceptions of sleep and sleep-disrupting factors in critically ill pediatric patients. Methodology: Convergent mixed-methods study comprising an exploratory qualitative and descriptive cross-sectional quantitative. For the qualitative component...

Gendered embodiment of sedentary behaviour and its impact on mental wellbeing in physiotherapy higher education: a sequential mixed methods study

Prolonged sedentary behaviour (SB) among university students is a growing concern, yet its impact on mental wellbeing (MWB) cannot be fully understood without considering its embodied nature: how it is experienced through the body in relation to social expectations. This study em...

Smoking cessation experiences during alcohol and cannabis treatment in substance use programmes in Catalonia: A qualitative study

Tobacco use remains disproportionately high among people receiving treatment for alcohol or cannabis use, yet it is rarely addressed in substance use services. This study explored the lived experiences of people who smoke while undergoing treatment for alcohol and/or cannabis use...