Universitas Muhammadiyah Riau

Design and synthesis of 6-chloro-1,3,5-triazine-2,4-diamine linked chalcone derivatives and their antimalarial activity evaluation

A series of nine triazine-chalcone hybrid compounds (7a–i) were designed and synthesized through a molecular hybridization strategy integrating 1,3,5-triazine and chalcone moieties. The hybrids were synthesized via sequential nucleophilic substitution reactions and characterized...