Universitair Ziekenhuis Brussel

Premedication practices prior to neonatal laryngoscopy: a nationwide observational study in Belgian NICUs

Intubation or less invasive surfactant administration (LISA) in neonates both require laryngoscopy, a stressful and painful procedure. This study aimed to document premedication practices before laryngoscopy in Belgium and explore reasons for absence of premedication. Sub-analysi...

Bacterial orbital infection leading to orbital exenteration: a case series

Orbital exenteration (OE) secondary to infection is rare. This case series reports 3 cases and aims to elucidate the possible underlying etiopathogenesis. A retrospective data analysis was performed of patients who underwent an OE and subsequently received an orbital prosthesis f...

The gut microbiome in multiple myeloma: from disease evolution to therapeutic modulation

The therapeutic landscape of Multiple Myeloma (MM), the second most common haematological malignancy, has undergone a paradigm shift with the introduction of anti-CD38 targeting monoclonal antibodies, immunomodulatory drugs and B-cell maturation antigen (BCMA) targeting Chimeric...

Mental health and substance use in Europe: initial steps towards a common European approach

BACKGROUND AND AIMS: Comorbid substance use and other mental health disorders contribute to more than one million years lived with disability in Europe according to the Global Burden of Disease study. They require a comprehensive approach, yet, in Europe, there is considerable va...

The enduring role of sulfasalazine in the treatment of juvenile idiopathic arthritis: a retrospective cohort study on safety and effectiveness

Abstract Background Sulfasalazine (SSZ) is a commonly used disease-modifying antirheumatic drug for juvenile idiopathic arthritis (JIA) that is primarily recommended within the group of juvenile spondyloarthropathies. Current treatment guidelines increasingly limit its role in th...

BIOCOST: A Costing Tool for Belgian Biobanks

BACKGROUND: Biobanks are essential infrastructures for biomedical research, yet their long-term sustainability is increasingly challenged by complex and often underestimated costs. While numerous cost-accounting approaches have been proposed over the past decade, comparable empir...

Exploring the organisation, operation and inquiries of Centres for Medicines Information: insights from a narrative review and questionnaire

Objectives Centres for Medicines Information (CMIs) are core components in providing evidence-based recommendations to practitioners, thus reducing medication errors. This study examined the organisational and operational features of international CMIs and the types of inquiries...

MRI Proton Density Fat Fraction as a Biomarker of Marrow Recovery Following Organ‐Sparing Total Marrow Irradiation in Sickle Cell Disease

BACKGROUND: Noninvasive quantitative assessment of marrow recovery after curative therapies such as total marrow irradiation (TMI) and bone marrow transplantation (BMT) remain poorly defined, particularly in sickle cell disease (SCD). PURPOSE: To evaluate MRI-derived proton densi...

Influences of socioeconomic and environmental factors on STEMI incidence and related mortality: Insights from the Belgian Environmental Myocardial Infarction Risk (EMIR) Study

Abstract Background Current risk models for myocardial infarction incidence and post-event mortality primarily rely on clinical parameters and do not account for environmental or socioeconomic factors. We aimed to provide a more comprehensive assessment of determinants of ST-elev...

Micro-CT radiomics reveals the microcalcification-surrounding tissue interface as the diagnostic epicenter of breast microcalcifications

In clinical breast imaging, microcalcifications (MCs) are routinely interpreted as small radiological signs, typically analyzed in clusters. They guide radiologists in assessing breast lesions and determining the likelihood of malignancy. Yet, increasing biological evidence indic...