Università di Camerino

Celastrol and Its Derivatives in Breast, Ovarian, and Cervical Cancer: Molecular Targets, Signalling Networks, and Nanocarrier-Based Delivery

Celastrol, a quinone methide pentacyclic triterpenoid obtained mainly from the roots of Tripterygium wilfordii Hook. f., forms covalent, often reversible, adducts with cysteine thiols in regulatory proteins, which underlies its multi-targeted action. This review summarises the pr...

Sequence‐Controlled Copolymers Through Selective Ring‐Opening Polymerization of Multiunit Macrolactones

ABSTRACT A new strategy for the synthesis of sequence‐controlled polymers (SCP), in which increased ester reactivity by the introduction of neighboring glycolate units within a multiunit macrolactone, was developed. DFT calculations and model reactions show that the proximity of...

Postbiotic polysaccharide and peptide-enriched electrospun nanofibers based on polycaprolactone/ethyl cellulose/sodium alginate as bioactive macromolecular matrices for aflatoxin M1 adsorption in milk

Abstract Aflatoxin M1 (AFM1) contamination in dairy products raises many food safety concerns due to its toxicity and resistance to conventional processes. In this study, a novel bio-based adsorption system was developed using electrospun polycaprolactone/ethyl cellulose/sodium a...

Community assembly on inland cliffs is context‐dependent

Abstract Under harsh environmental conditions, community assembly processes are expected to drive pronounced functional convergence, with communities dominated by stress‐tolerant species. Integrating local communities with their regional species pools enables evaluating environme...

Two-dimensional shear wave elastography assessment of testicular stiffness in healthy cats

Two-dimensional shear wave elastography (2D-SWE) provides quantitative information on tissue stiffness over a broad field of view, but physiological values for feline testes remain poorly defined. This study aimed to characterize testicular stiffness in clinically healthy cats an...

Ligand Engineering Controls Near-Infrared Emission, Quantum Efficiency, and Photoluminescence Lifetimes in Dimetallic Ru(II) Complexes

Abstract The exceptional photophysical and electrochemical properties of Ru(II) complexes support broad applications in optoelectronic functional materials and bioimaging, particularly those Ru(II) complexes which show near-infrared (NIR) luminescence. This study reports ligands...

Adsorption Behavior of C10 Amino Acid Surfactants at the Air/Water Interface: Implications for Membrane Compatibility

Abstract Amino acid-based surfactants represent a promising class of biocompatible and biodegradable amphiphiles with increasing relevance in pharmaceutical and biomedical applications. Despite their growing use, a quantitative understanding of their interfacial packing and how t...

Cross-cohort transcriptional and network signatures of human papillomavirus-associated cancers

Introduction: Persistent human papillomavirus (HPV) infection contributes substantially to the global burden of virus-associated cancers, including those of the cervix, vulva, anus, penis, and oropharynx. HPV-positive tumors frequently exhibit distinct clinical characteristics. T...

Polycyclic aromatic hydrocarbons in loggerhead sea turtles (Caretta caretta) embryos: Occurrence, tissue distribution and associated biological responses

Maternal transfer of environmental contaminants represents a critical pathway that occurs during the early life stages of marine vertebrates, however, the occurrence and the fate of polycyclic aromatic hydrocarbons (PAHs) in sea turtle embryos remain poorly characterized. This st...

Similar pre-eruptive conditions behind contrasting explosive and effusive trachytic eruptions at Montagnone (Ischia volcano, Italy)

Abstract Most volcanoes on Earth display a range of eruptive styles, varying between effusive and explosive activity. Understanding the factors controlling these transitions is critical for volcanic hazard assessment but remains debated. While both pre-eruptive storage conditions...

Synergy of Phenylsilsesquioxane and Pyridylpyrazolate Ligands in Hexacopper Cages: Approach to Catalytic Toluene Oxidation

Abstract Cage-like Cu6M2 (M = Li or Na) complexes, containing two pairs of ligands, Si5-cyclic silsesquioxanes and pyrazolylpyridines, have been obtained. Two central (Cu···Cu···Cu···M) tetramers are sandwiched by Si ligands, while pyrazolylpyridines behave simultaneously in chel...

Redox Halido‐Based Reactivity on the Addition of Bromine to Linear NHC Gold Halides

Halogen addition to a linear gold complex to form a square‐planar species is one of the most representative examples of what is generally classified as an “oxidative addition” process. This work examines the addition of bromine to the linear complexes labeled as NHC Me, Bn AuX (w...

Refined Shrimp Peptide Concentrate: Regulatory, Value Chain and Circular Blue Bioeconomy Perspectives

The European Union Regulation (EU) 2015/2283 on novel foods has created new opportunities for the valorization of marine by-products within the framework of the circular bioeconomy and sustainable blue economy. Refined shrimp peptide concentrate (RSPC), obtained through enzymatic...

Effects of multi-scale drivers on plant diversity and forage quality in traditional wood-pastures of Transylvania (Romania)

Traditional wood-pastures are agroforestry systems shaped by long-term low-intensity management. However, the relative importance of drivers of plant diversity and forage quality operating at different spatial scales in these systems remains poorly understood. We investigated 30...

Cortical dynamics in Angelman syndrome: novel insights from a preclinical mouse model

Angelman syndrome (AS) is a neurogenetic disorder caused by the loss of function in the maternally inherited UBE3A gene, leading to a spectrum of symptoms that include developmental delays, intellectual disability, and motor impairments. While genetic and molecular mechanisms of...

Soil health assessment using buried cotton underpants with the help of 1000 citizen scientists

Societal Impact Statement Soil is a vital resource for life on Earth. Although many soils are degraded, societal awareness of soil‐related issues is limited. To highlight soil as a key resource and fascinating study system, we initiated a citizen science project together with 100...

Best practices to master robotic preparation of ready-to-administer systemic anticancer therapy in hospital pharmacies

Automated reconstitution or preparation of systemic anticancer therapy has gained traction in the past decade. Transitioning from traditional manual workflows to fully automated production offers multiple benefits: decreased pharmacy staff workload, reduced risk of repetitive str...

Comparative cytoarchitectural and proteomic analysis of the primary motor cortex in pigs and wild boars reveals domestication associated changes

Background Domestication appears to modify the morphology and physiology of the central nervous system. Owing to the limited availability of proteomic and cytoarchitectural data for comparisons between wild and domesticated species, we conducted a comparative analysis of the cyto...

Contrasting eruptive dynamics and hazards of two Holocene andesitic sub-Plinian to Plinian eruptions, Lower and Upper Citlaltépetl, at Pico de Orizaba, Mexico

Abstract Pico de Orizaba (Citlaltépetl) stratovolcano, eastern Mexico, preserves a complex Holocene explosive record, yet the eruptive dynamics, source parameters, styles, and hazard implications of individual eruptive episodes remain poorly constrained. Here, we examine the 9600...