Universidade São Francisco

(±)-Nigronetides A−D and Nigronetides E−H, Complex Polyketides Produced by the Marine-Derived Fungus Nigrograna sp. M13

Abstract (±)-Nigronetides A−D (1−4) and nigronetides E−H (5−8), polyketides with complex carbon skeletons, were isolated from cultures of the marine-derived fungus Nigrograna sp. M13, presenting three novel carbon skeletons. While the planar structures and relative configuration...

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human...

Medial Patellofemoral and Medial Patellotibial Ligament Reconstruction Using a Docked Rectus Femoris Graft

Abstract Recurrent patellar instability may persist after isolated medial patellofemoral ligament reconstruction, particularly in cases with instability beyond early knee flexion. Recent evidence has emphasized the role of the medial patellotibial ligament as a secondary stabiliz...

Age-related variation in heart rate variability across receptor-defined breast cancer groups, with distinct patterns in triple-negative disease: a cross-sectional study

Breast cancer (BC) is the most common malignancy among women worldwide, and growing evidence suggests that autonomic nervous system (ANS) activity modulates tumor biology and the tumor microenvironment. Heart rate variability (HRV), a non-invasive index of ANS balance, is influen...

He who pays the piper calls the tune? Capital structure and ESG performance in emerging markets

Purpose This study analyzes the association between capital structure and the environmental, social, and governance (ESG) performance among companies in emerging markets. Design/methodology/approach Using data from the London Stock Exchange Group covering 24 emerging markets and...

Self-medication and psychological symptoms among undergraduate health science students: exploratory associations with religiousness and spirituality in a cross-sectional study

Undergraduate health science students experience academic, clinical, and social demands that may affect psychological well-being and influence self-care practices, including self-medication. Religiousness and spirituality may be associated with how students experience and interpr...

Hypokalemic Hypochloremic Metabolic Alkalosis in Cystic Fibrosis: A Retrospective Observational Study with Clinical Characterization, CFTR Genetic Profiling, and a Comparative Genetic Analysis with Patients from a Brazilian Reference Center

Cystic fibrosis is a genetic disorder caused by pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and may be complicated by hypokalemic hypochloremic metabolic alkalosis (HHMA), resulting from excessive electrolyte loss through sweat. This...

Rigorous ground plans as terminal taxa: a demonstration in Gastropoda (Mollusca), focusing on Caenogastropoda

Despite being widely discussed, the use of ground plans (or ground patterns) as terminals in phylogenetic analyses often faces bias during peer review, as evidenced by criticisms of phylogenetic studies. A ground plan can be defined as the sum of all character states associated w...

Operationalizing High Ischemic Risk After the 2026 ACC Scientific Statement: a disease-based, bleeding-filtered algorithm for aspirin in primary prevention

PREPRINT, NOT PEER REVIEWED. Deposited to establish a dated public record of authorship while the manuscript is under journal review. Background and aims. Guideline statements sometimes name a treatment target without an operational definition. The 2026 American College of Cardio...

Operationalizing High Ischemic Risk After the 2026 ACC Scientific Statement: a disease-based, bleeding-filtered algorithm for aspirin in primary prevention

PREPRINT, NOT PEER REVIEWED. Deposited to establish a dated public record of authorship while the manuscript is under journal review. Background and aims. Guideline statements sometimes name a treatment target without an operational definition. The 2026 American College of Cardio...

Frequency and Association between Adverse Childhood Experiences and Psychiatric Outcomes Among Treatment-seeking Patients with Severe Obesity: a Retrospective Observational Study

Abstract Introduction Adverse childhood experiences (ACEs) are well-established risk factors for obesity and psychiatric disorders in adulthood. Despite growing evidence, the association of specific ACE categories with the mental health of patients with severe obesity remains poo...

Endovascular therapy versus best medical treatment in pediatric acute ischemic stroke: A systematic review and meta-analysis

Purpose This systematic review and meta-analysis evaluates endovascular therapy (EVT) versus best medical treatment (BMT) in pediatric acute ischemic stroke (AIS) due to large-vessel occlusion. Methods Systematic searches were conducted across PubMed, Cochrane, and Embase, incept...

Single and MultipleInfestation by Coccoid Pests inCoffee Shape Plant Chemical Defenses and Interactions Across TrophicLevels

Abstract Crop plants are attacked by multiple pests, inducing metabolic changes that shape interactions across trophic levels and influence the effectiveness of biological control. We examined how infestation by the coccoids Coccus viridis (scales) and Planococcus citri (mealybug...