Universidade Regional Integrada do Alto Uruguai e das Missões

Spatially Extensive Snapshot Sampling Reveals Regional Turnover and Complements Temporal Surveys of Drosophilidae in Southern Brazil

Sampling design strongly influences which components of biodiversity are recovered in regional inventories. We evaluated a spatially extensive snapshot survey of Drosophilidae assemblages in southern Brazil and compared it with temporally repeated datasets from the same broad reg...

Modulation of the Endocannabinoid System by Cannabis sativa Bioactives in Alzheimer’s Disease: Therapeutic and Nutritional Implications

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, neuroinflammation, oxidative stress, amyloid-β accumulation, and tau pathology. Current therapies provide limited symptomatic relief, highlighting the need for nov...

Underestimated ecological risks of 2,4-D in aquatic systems revealed by sublethal effects and recovery assessment

Pesticides are widely detected in aquatic environments, raising concerns about ecological risks not captured by conventional toxicity assessments. The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is extensively used, yet its sublethal effects and the reversibility of those ef...

Sustainable production of poly(3-hydroxybutyrate) by Bacillus megaterium ATCC 14581: Kinetic and stoichiometric parameters of fed-batch production, ultrasound-assisted recovery, and characterization

The growing demand for bio-based materials has stimulated the development of sustainable alternatives to conventional plastics, among which polyhydroxyalkanoates (PHAs) stand out due to their biodegradability and biocompatibility. In this context, the present study evaluated the...

L-carnitine modulates molecular responses associated with inflammation, endoplasmic reticulum stress, and neurotrophic signaling in cerebral cortex of neonatal Gcdh−/− mice exposed to glutaric and quinolinic acids

Abstract Glutaric acidemia type 1 (GA I) is caused by deficient activity of glutaryl-CoA dehydrogenase, leading to predominant accumulation of glutaric acid (GA) in the brain. GA I patients present progressive neurological deterioration whose pathophysiology is only partially elu...

Second-generation bioethanol from lignocellulosic biomass: An integration-oriented review of pretreatment, bioconversion, techno-economic assessment, and industrial perspectives

The growing demand for sustainable energy and the environmental impacts of fossil fuel use have accelerated the development of renewable alternatives, particularly biofuels. Among them, second-generation (2G) ethanol produced from lignocellulosic biomass has emerged as a promisin...