Universidade Regional do Cariri

Multi-Target Analysis of Xanthone Derivatives as Potential Anti-Trypanosoma cruzi Agents: An Integrated Computational Screening

Chagas disease, caused by the parasite Trypanosoma cruzi , affects approximately 8 million people worldwide. The search for new therapeutic candidates is intensified by the limited efficacy and severe adverse effects of current treatments, such as benznidazole and nifurtimox. In...

Mapping the IntermolecularInteraction Landscape ina New Nicotinamide–Undecanoic Acid Cocrystal: SupramolecularStructure, Spectroscopic Analyses, and Computational Studies

Abstract A novel cocrystal composed of nicotinamide (NA) and undecanoic acid (UA) in a 1:1 stoichiometry has been successfully synthesized via slow evaporation and comprehensively characterized through a multidisciplinary approach combining experimental and computational methods....

Beyond binary urban-rural classifications: a continuous urbanicity gradient index

Abstract Traditional urban-rural dichotomies fail to capture the complexity of contemporary settlement patterns, constraining both scientific progress and policy applications in urbanization research. To address this gap, we introduce the Urbanicity Gradient Index (UGI), a contin...