Universidade Regional do Cariri

From Waste to Resource: Upcycling Spent Coffee Grounds into Biochar Functionalized with CaFe2O4 for Phosphate Removal

Abstract Eutrophication caused by excess phosphorus in water bodies represents a significant environmental challenge, requiring efficient, selective, and sustainable technologies for its mitigation. In this study, a magnetic biochar (BiMag) was developed through the valorization...

Fungistatic Potential and Inhibition of Fungal Yeast-hyphae switch of Candida spp. by Hecogenin Acetate

Invasive fungal infections represent one of the leading causes of morbidity and mortality in immunocompromised patients, and many of the currently available antifungal agents are associated with toxicity, recurrence, or the development of resistance. Plants are a promising source...

Protective effect of lycopene against sodium nitroprusside-induced oxidative stress in Artemia salina

Lycopene is a carotenoid with potent antioxidant properties, that is widely used in the food, pharmaceutical, and cosmetic industries, thereby increasing the likelihood of its release into aquatic environments through industrial effluents. Artemia salina is a well-established eco...

The Colina do Horto Geosite in the Araripe UNESCO Global Geopark, Brazil: Archaeology of the Contemporary and Cultural Landscape

Abstract This article analyzes the Colina do Horto Geosite, located within the Araripe UNESCO Global Geopark (Northeastern Brazil), through an integrated approach that combines geodiversity, archaeology, and cultural landscape approaches, grounded in the theoretical and methodolo...

The top 100 cited papers in AI and Healthcare: trends, collaborations, and key contributions

Abstract Purpose This study performed a bibliometric analysis of the top 100 most cited papers on artificial intelligence (AI) and its applications in health and medicine. Data was retrieved from the Scopus database in December 2024, focusing on papers published between 2001 and...

Molecular insights and ADMET profiling of iridoids as candidate leads for erectile dysfunction therapy

Abstract Context Erectile dysfunction (ED) significantly affects male psychosocial health and has an increasing incidence. Although phosphodiesterase 5 (PDEi-5) inhibitors are the first-line therapy, the occurrence of visual side effects resulting from cross-inhibition of the PDE...

Multi-Target Analysis of Xanthone Derivatives as Potential Anti-Trypanosoma cruzi Agents: An Integrated Computational Screening

Chagas disease, caused by the parasite Trypanosoma cruzi , affects approximately 8 million people worldwide. The search for new therapeutic candidates is intensified by the limited efficacy and severe adverse effects of current treatments, such as benznidazole and nifurtimox. In...

Mapping the IntermolecularInteraction Landscape ina New Nicotinamide–Undecanoic Acid Cocrystal: SupramolecularStructure, Spectroscopic Analyses, and Computational Studies

Abstract A novel cocrystal composed of nicotinamide (NA) and undecanoic acid (UA) in a 1:1 stoichiometry has been successfully synthesized via slow evaporation and comprehensively characterized through a multidisciplinary approach combining experimental and computational methods....

Beyond binary urban-rural classifications: a continuous urbanicity gradient index

Abstract Traditional urban-rural dichotomies fail to capture the complexity of contemporary settlement patterns, constraining both scientific progress and policy applications in urbanization research. To address this gap, we introduce the Urbanicity Gradient Index (UGI), a contin...