Universidade Iguaçu

Novel Synthetic Chalcones Display Potent Anti- Leishmania ( Viannia ) braziliensis Profile and Inhibit Proteolytic Activities

Abstract American Tegumentary Leishmaniasis, primarily caused by Leishmania (Viannia) braziliensis, remains a major public health challenge in Latin America. The variable efficacy and toxicity of pentavalent antimonials underscore the urgent need for new therapeutic candidates. A...

Ligation of the canine mesovarium with a resorbable self-locking device: a multicentre study

Abstract Background Haemorrhage from the ovarian pedicle is a known complication at removal of ovaries in dogs. A resorbable self-locking device designed for surgical ligation was previously developed, aimed to keep the advantage of a self-locking loop at ligation and avoid the c...

Anion States andDissociation Pathways of the UniversalRadiosensitizer Model 2,4-Dichloro-5-nitropyrimidine

Abstract We present a computational investigation into the anion states of 2,4-dichloro-5-nitropyrimidine (NDP), focusing on dissociative electron attachment pathways motivated by recent mass spectrometry experiments. The molecule exhibits a unique combination of low-energy elect...