Universidade Federal do Piauí

VLA-4 integrin modulates cellular responses to sorafenib in metastasis-related processes of B16F10 melanoma cells

Metastatic progression in melanoma is driven by the coordinated activity of adhesion molecules and growth factor receptors, yet the functional interplay between integrins and VEGFR-related signaling remains poorly defined. This study investigated the role of α4β1 integrin, also k...

Macroecological invisibility in apple snails (Gastropoda: Ampullariidae): uneven occurrence and molecular coverage across public repositories

Abstract Apple snails (Ampullariidae) are freshwater gastropods of ecological and economic importance, but their digital representation remains uneven across taxa, regions and data types. Using a 171-species taxonomic reference, we integrated global occurrence and molecular data...

Surface Topography Improvement of Micro-Milled Inconel 718 Slots Through Abrasive Deburring: Comparison Between Polishing and Sanding

Burr formation remains a major challenge in micro milling due to reduced tool dimensions and size-effect phenomena, particularly when machining difficult-to-cut materials such as Inconel 718. This study compares the effectiveness of two abrasive deburring processes, polishing and...

Endovascular therapy versus best medical treatment in pediatric acute ischemic stroke: A systematic review and meta-analysis

Purpose This systematic review and meta-analysis evaluates endovascular therapy (EVT) versus best medical treatment (BMT) in pediatric acute ischemic stroke (AIS) due to large-vessel occlusion. Methods Systematic searches were conducted across PubMed, Cochrane, and Embase, incept...

Smart Coatings Integrating Antimicrobial and Tissue‐Remodeling Functions for Implant Interfaces

AIM: This study aimed to assess the antimicrobial performance and biocompatibility of our drug delivery platform, based on layer-by-layer (LbL) coating incorporating tetracycline (TC) complexed with anionic β-cyclodextrin (TCβCD) and a pH-responsive poly(methacrylic acid) (PMAA)...

Modulation of Advanced Glycation End Products and Oxidative Stress by Hesperetin-7-O-Glucoside and Diosmetin-7-O-Glucoside Complexed with Cyclodextrins

Background/Objectives: Chronic complications of diabetes mellitus are closely associated with increased oxidative stress and the formation of advanced glycation end products (AGEs). This study aimed to investigate the antioxidant and antiglycation potential of hesperetin-7-O-gluc...

Role of atmospheric sulfate from industrial gypsum emissions in shaping soil solution chemistry and aluminum speciation along the soil profile

, indicating vertical redistribution driven by water fluxes. PCA identified sulfate as the primary variable governing the organization of soil solution chemistry along the soil profile. Overall, these findings demonstrate that continuous atmospheric sulfate deposition from indust...