Universidade Federal do Pará

Exploring genetic variability in FOXE1 through in silico approaches: new insights on UTR variants

<title>Abstract</title> The <italic>FOXE1</italic> gene is a transcription factor critical for thyroid development and function, and has been associated with thyroid disorders and other phenotypic traits like cancer and orofacial clefts. This study explores the genetic variabilit...

Mapping the IntermolecularInteraction Landscape ina New Nicotinamide–Undecanoic Acid Cocrystal: SupramolecularStructure, Spectroscopic Analyses, and Computational Studies

Abstract A novel cocrystal composed of nicotinamide (NA) and undecanoic acid (UA) in a 1:1 stoichiometry has been successfully synthesized via slow evaporation and comprehensively characterized through a multidisciplinary approach combining experimental and computational methods....

Persistent Redox Imbalance in Post-COVID-19 Syndrome: Lipid Peroxidation, Antioxidant Enzyme Depletion, and Reduced Nitric Oxide Availability in an Amazonian Population

Post-COVID-19 syndrome (PCS) can persist even after mild acute illness, and oxidative stress has been proposed as a central mechanism for this persistence, although it remains poorly studied in the Amazon. This study characterized redox imbalance in patients with PCS through a co...

Platelets as regulators of cancer immunity: mechanisms and therapeutic perspectives

Abstract Platelets correspond to one of the most abundant components of the blood and shape the tumor microenvironment, modulate antitumor immune responses, and influence clinical outcomes in cancer patients. Recent studies have expanded our understanding of the mechanisms underl...

Cation-Disordered TbNdFeCoO6 Double Perovskite: Structural, Vibrational, Magnetic, and Electrocatalytic Insights for Efficient Hydrogen Evolution Reaction

Abstract Double perovskite oxides have emerged as promising multifunctional materials for sustainable energy applications due to their tunable structural, electronic, magnetic, and electrocatalytic properties. In this research study, the cation-disordered double perovskite TbNdFe...

Microplastic Occurrence in Foragers of Two Neotropical Bee Species (Apidae: Meliponini) from the Eastern Amazon

Abstract Microplastics (MPs) are ubiquitous anthropogenic pollutants that originate from diverse sources and pose a significant threat to both aquatic and terrestrial ecosystems. Bees are considered active bio-samplers of air quality due to the accumulation of MPs on their bodies...

Evaluating the mud filtrate on the well-seismic tie and its impacts on elastic properties using Gassmann modeling and sparse-spike deconvolution in the Norne field

Abstract The well-seismic tie process is critical for integrating well and seismic data to achieve accurate subsurface interpretations. While previous studies have investigated the influence of mud filtrate invasion on well-log responses, its impact on seismic calibration remains...

Global trends in artificial intelligence applications in medical imaging and implications for clinical practice

This study aimed to analyze the evolution of scientific production on AI applied to medical imaging, focusing on temporal trends, the global distribution of research, and trends in clinical applications. A bibliometric study was conducted using the Scopus and Web of Science datab...

Toroidal quasi-dark supermodes in microwave dielectric metasurfaces

We report a class of dielectric metasurfaces that support quasi-dark microwave resonances with tailored toroidal and antitoroidal field profiles. The metasurfaces are realized using quadrumers of high-permittivity and low-loss ceramic disk resonators as elementary building blocks...

Diabetes Mellitus and Long-Distance Running: A Systematic Review

BACKGROUND: Athletes with diabetes increasingly participate in endurance running, benefiting from physiological adaptations and technological advances like continuous glucose monitoring (CGM) for glycemic control. So far, no comprehensive review summarizing the current knowledge...