Universidade Federal de Ciências da Saúde de Porto Alegre

Clozapine Across Treatment-Resistant Symptom Dimensions: A Conceptual Review and Transdiagnostic Rationale for Child and Adolescent Psychiatry

Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, yet in children and adolescents it remains off-label and underused, constrained by safety concerns and scarce pediatric-specific evidence. Its benefits may extend beyond any single diagnostic cat...

Applied nutritional investigation determinants of lower quadriceps skeletal muscle measured by ultrasound at ICU admission: a cross-sectional analysis

Background Low skeletal muscle (SM) is common at ICU admission and is associated with worse prognosis. Early identification of at-risk patients is essential, but determinants of low SM in critically ill patients remains unclear. Objective To identify sociodemographic, nutritional...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Solanum vegetables as potential neuroprotective functional foods in Alzheimer's disease management: A unifying mechanism

Alzheimer's disease (AD) is a multi-etiological neurological condition that requires a holistic therapeutic approach in its management. In view of this functional foods and nutraceuticals have become --promising candidates in AD research. This is because functional foods and nutr...

Broad-spectrum LC-MS/MS hair analysis for monitoring recreational drug use in electronic dance music festival attendees

Abstract Purpose Hair toxicological analysis enables the verification of long-term drug use monitoring and supports epidemiological studies. In recreational contexts, multi-analyte methods are crucial for accurately characterizing consumption patterns. The present work aimed to d...

Photobiomodulation therapy and postoperative recovery after abdominoplasty: a non-randomized pilot study

Abstract Photobiomodulation (PBM) has been proposed as a non-invasive therapeutic strategy to support wound healing and modulate oxidative and inflammatory responses. However, clinical data evaluating its effects in the postoperative period of abdominoplasty remain limited. This...

DOPAL links dopamine dysregulation to neurodegeneration: a translational systematic review and meta-analysis

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is the most reactive dopamine (DA)-derived aldehyde and has been implicated in selective dopaminergic neurodegeneration in α-synucleinopathies, including Parkinson’s disease (PD) and multiple system atrophy (MSA). Here, we present the first...

Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathways

Abstract COVID-19 and obesity are complex conditions marked by immune and metabolic dysfunction, with the former still ranking among the leading causes of death from infectious diseases worldwide and the latter reaching pandemic proportions. Clinical evidence consistently shows t...