Universidade Estadual do Piauí

Carcinogenic mechanisms in penile cancer: HPV, inflammation, and other pathways

Objective: Penile cancer, though rare, carries profound clinical and psychosocial consequences. Its diagnosis often occurs at advanced stages, leading to mutilating surgeries and severe impairment in quality of life. Approximately 95% of penile malignancies are squamous cell carc...

An observational assessment of soil physical, chemical, and biological attributes under contrasting land-use systems in Eastern Maranhão, Brazil

Abstract The adoption of integrated crop–livestock production systems, together with practices such as crop rotation, crop succession, and intercropping, has increased the need for integrated approaches to assess soil health. This study evaluated soil health under contrasting lan...

Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications

NPC2 is a lysosomal cholesterol transporter involved in intracellular lipid trafficking and cholesterol homeostasis, processes that have been increasingly implicated in cancer biology. To quantify the clinical impact of NPC2 expression across human malignancies, we analyzed survi...

Green Hydrogen in Brazilian Media: Dominant Narratives and Missing Dimensions of the Energy Trilemma

ABSTRACT Media discourses help shape the visibility and legitimacy of energy transition pathways in the public sphere. This study examines how Brazilian mainstream newspapers framed green hydrogen and assesses the alignment of these narratives with the energy trilemma: energy sec...

Woven endobridge device compared to stent-assisted coiling and microsurgical clipping for intracranial aneurysms

Background: Endovascular techniques and devices, including Woven EndoBridge (WEB) and stent-assisted coiling (SAC), expand the choice of therapies for complex aneurysms, while the evidence directly comparing them to microsurgical clipping (MSC) remains very limited. This meta-ana...

A mechanistic approach about oxidative, mutagenic, and cytotoxic effects of an organotellurane

Abstract Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic acti...

MultifunctionalHybrid Gels Containing Silver Nanoparticles,Gold Nanorods, and Protoporphyrin IX for Synergistic Photothermal–PhotodynamicTherapy

Abstract Photodynamic and photothermal therapies, enhanced by nanotechnology, show great potential in skin cancer treatment. This study reports the synthesis and characterization of hybrid sodium alginate gels conjugated with protoporphyrin-IX, associated with gold and silver nan...

Role of atmospheric sulfate from industrial gypsum emissions in shaping soil solution chemistry and aluminum speciation along the soil profile

, indicating vertical redistribution driven by water fluxes. PCA identified sulfate as the primary variable governing the organization of soil solution chemistry along the soil profile. Overall, these findings demonstrate that continuous atmospheric sulfate deposition from indust...