Universidad San Pablo CEU

Hybrid experimental–numerical methodology for the mechanical analysis of mortars containing recycled polymer inclusions

Abstract This investigation presents a hybrid experimental–numerical methodology for evaluating the mechanical behavior of mortars containing recycled polymer inclusions. Mortar mixtures incorporating recycled polyethylene terephthalate (PET) and polyamide 6 (PA6) at replacement...

Computationally Guided Design and Experimental Validation of ssDNA Aptamers Targeting the SARS-CoV-2 Spike Protein

Aptamer development has traditionally relied on iterative, labor-intensive experimental approaches. Recent advances in bioinformatics and computational power now enable the rational in silico design of high-affinity nucleic acid ligands, drastically reducing time and cost. Here,...

Generative synthesis of high-fidelity pathological brain MRI via label-conditioned latent diffusion

The synthesis of high-fidelity brain Magnetic Resonance Imaging (MRI) is essential for addressing data scarcity and privacy constraints in medical research. In this study, we present a Latent Diffusion Model (LDM) for conditional MRI generation, operating in a compressed latent s...

Clinical Complications of Fixed Anterior Prostheses After Traumatic Premature Loss of Primary Maxillary Incisors: A Retrospective Cohort Study

BACKGROUND/AIM: Premature loss of primary maxillary incisors after traumatic dental injuries may require secondary rehabilitation in preschool children. Evidence on complications associated with fixed anterior prostheses in this context remains limited. This retrospective cohort...

Antibody-drug conjugate engineering: from design to efficacy and safety

Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimizatio...

Molecular characterization of tetraploid astrocytes in drug-resistant temporal lobe epilepsy

Epilepsy is one of the most prevalent neurological diseases, with 25–33% of patients developing drug-resistant epilepsy (DRE). The precise etiology of DRE remains unidentified. Recent studies have revealed an increase in tetraploid astrocytes in drug-resistant temporal lobe epile...

Soil regeneration using wastewater treatment plant sludge and plant growth-promoting bacteria in Quercus ilex: implications for antibiotic resistance within a One Health framework

Soil degradation is a critical problem in Spain, aggravated by intensive agricultural practices, urbanisation and natural phenomena such as forest fires. This study addresses soil regeneration through the valorisation of waste from wastewater treatment plants (WWTP) and its suppl...

A Bacillus pretiosus Biofertilizer Enhances Early Growth, Nutritional Profile, and Rhizospheric Dynamics in Quercus Species for Forest Restoration

Plant growth-promoting bacteria (PGPBs) have emerged as essential biological inputs to improve the establishment, physiological performance and survival of forest species used in ecological restoration programs. The decline of Quercus forests throughout the Mediterranean basin re...

Endocannabinoid system dysregulation in oral diseases: mechanistic insights and therapeutic modulation

Abstract Background Chronic inflammatory and neoplastic diseases of the oral cavity, including periodontitis, oral lichen planus (OLP), oral squamous cell carcinoma (OSCC), and oral mucositis, represent a significant global health burden. Current therapeutic strategies face limit...

The role of internal capabilities and external pressures in sustainable energy management adoption in Vietnamese firms

Vietnam’s rapid industrial growth and weak environmental performance make firm-level sustainable energy management practices increasingly urgent, yet evidence remains limited on how internal capabilities, external pressures, and managerial experience shape their adoption in emerg...

Effects of body weight support and walking speed on device-derived hip angles and muscle activity symmetry during overground robotic-assisted walking in older adults

Understanding how body weight support (BWS) and walking speed influence gait in older adults may help guide the selection of assistance settings during robotic-assisted gait rehabilitation. These parameters are routinely adjusted during clinical practice, yet their effects during...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Caregivers and technology: Digital content assessment on Alzheimer’s disease

Methods This study examined caregivers' preferences for digital content to support the care of individuals with dementia, particularly those with Alzheimer's disease (AD). An online survey was conducted with 147 caregivers affiliated with the Pasqual Maragall Foundation, assessin...