Universidad Peruana Cayetano Heredia

Organized communities as pre-existing infrastructures of care during the COVID-19 pandemic: A transnational dialogue

This article draws from a community-engaged study of how ordinary people's social justice mobilization during the COVID-19 pandemic in Brazil, Canada, Germany, and Peru placed demands on local and national governments for equitable social policies. It challenges celebratory narra...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Antiproteinuric Response to Finerenone in Diabetic Kidney Disease: Responder and Non-Responder Subgroup Analysis of the FINDKDLATAM Study

Background/Objectives: Albuminuria is an early marker of kidney damage and an independent predictor of adverse outcomes, making its reduction a key therapeutic goal. Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, has demonstrated renal and cardiovascu...

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America

Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is unknown. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy, tolerability and safety of different pri...

Low-pressure pneumoperitoneum in robot-assisted radical prostatectomy: a systematic review, meta-analysis and trial sequential analysis of randomized controlled trials

Abstract Purpose Low-pressure (LP) pneumoperitoneum (intra-abdominal pressure [IAP] <12 mmHg) has been proposed to reduce pain after robot-assisted radical prostatectomy (RARP), but earlier syntheses combined randomized with non-randomized data, pooled mixed urological procedures...

Assessing Emergency Clinicians' Needs From Trauma Clinical Guidance: A Mixed-Methods Study.

BACKGROUND: In the United States, emergency clinicians are often the first to care for injured patients in the hospital setting. Current trauma clinical guidance does not consistently meet the needs of emergency clinicians caring for this population. OBJECTIVES: To better underst...

HIV and STI Co-infection and Migration-Related Social Vulnerability among Venezuelan Gay and Bisexual Migrants in Lima, Peru

BACKGROUND: This study examined HIV, bacterial STI co-infection, and migration-related vulnerability among Venezuelan gay, bisexual, and other men who have sex with men (GBM) in Lima, Peru. METHODS: A total of 306 Venezuelan GBM of any serostatus living in Lima, Peru, were recrui...

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

Safety, efficacy and angiographic outcomes of the Lattice flow diverter for intracranial aneurysms: A systematic review and meta-analysis

Introduction The Lattice flow diverter is a novel mechanical balloon-based device designed to enhance wall apposition and optimize aneurysm neck coverage. Yet, its safety, efficacy, and angiographic outcomes have not been systematically evaluated. Methods A systematic review and...

Whole-cell surface-display system in attenuated Salmonella Enteritidis for slide microagglutination-based antibody detection

Abstract Background Microagglutination is a sensitive, rapid, and cost-effective serological assay widely used for disease diagnosis and surveillance in animals and humans. However, it traditionally relies on culturing live pathogenic bacteria as antigens, posing biosafety risks,...