Universidad Nacional de Río Cuarto

Synthon-Based Crystal Engineering of Mebendazolium Tosylates: Solid-Form Design, Structure−Property Relationships, and Enhanced Solubility from Experimental and DFT Studies

Abstract Salt formation is a well-established crystal engineering strategy to modulate the physicochemical and pharmacokinetic properties of active pharmaceutical ingredients. In the case of mebendazole (MBZ), a broad-spectrum anthelmintic, this approach has been successfully emp...

Persistent Menthol Hydrogen-Bonding Networks Govern the Structure and Hydration of a Hydrophobic Natural Deep Eutectic Solvent: Insights from NMR and Molecular Dynamics Simulations of the Camphor–Menthol System

Abstract Natural deep eutectic solvents (NADES) based on monoterpenoids have emerged as promising hydrophobic, biodegradable media. Despite their widespread use, the molecular interactions governing the formation and hydration behavior of camphor–menthol NADES remain insufficient...

Fabrication of Polypyrrole Functional Nanofilms by Nucleophilic Addition—Part I: Synthesis and Characterization

Polypyrrole (PPy) nanofilms were deposited by in situ chemical oxidative polymerization on polyethylene or polypropylene. The thickness is determined by SEM of the cross-section. Thin thickness nanofilms (180 ± 5 nm) are deposited. The nanofilms are then modified by nucleophilic...

Physicochemical design and in vitro biocompatibility of thermoresponsive PNIPAM nanogels as biomedical nanoplatforms

Smart drug delivery systems have attracted considerable interest in nanomedicine because they enable controlled release of therapeutic agents. Among them, poly(N-isopropylacrylamide) (PNIPAM) nanogels are promising candidates owing to their thermoresponsive behavior. However, the...

Borderline Personality Disorder: Assessment from an Integrative Dimensional and Categorical Perspective

Abstract This study examines the psychometric properties of the Borderline Personality Disorder (BPD) subscale of the Scale of Externalizing Behavior Problems in Adults (SEPBA-BPD). This instrument is designed to assess BPD from an integrative perspective, incorporating both cont...

Fluorene- and Xanthene-Based Redox Mediators for Li–O2 Batteries: From Spiro-Linkage to Solo Moieties

Abstract Soluble charge redox mediators (RMs) are key to improving the reversibility and efficiency of lithium–oxygen (Li–O2) batteries by facilitating the oxidation of discharge products and reducing charge overpotentials. In this work, we report on two prospective RMs, F-OMeTAD...