Universidad Nacional de Asunción

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Impulsive Release Strategies for Wolbachia-Infected Mosquitoes Under Temperature-Induced Infection Loss

Abstract The release of Wolbachia -infected mosquitoes is a promising strategy for controlling Aedes aegypti populations, although high-temperature exposure may temporarily reduce infection levels and compromise long-term persistence. We propose a population-dynamics model based...

Forty-five years of academic neurosurgery in Paraguay: A systematic review and bibliometric analysis of the transition to self-reliance

Background: While the global neurosurgical burden is highest in low- and middle-income countries, scientific output remains dominated by high-income nations. Paraguay has seen a dramatic seven-fold increase in its neurosurgical workforce since 1980, yet its academic footprint rem...

Acrocomia aculeata (Mbokaja) Kernel Oil Inhibits Herpes Simplex Virus 1 Replication and Promotes Cutaneous Wound Healing in Infected Mice

Background/Objectives: Herpes simplex virus type 1 (HSV-1) is a global and prevalent pathogen, presenting significant clinical challenges because of its recurring infections, the development of drug resistance and severe clinical complications. This study evaluated the antiviral...

War, climate change, and mental health: a geopsychiatric perspective on an emerging global polycrisis

Abstract Background War, armed conflict, forced displacement, and climate change are increasingly interconnected determinants of mental health. A geopsychiatric perspective situates their effects within the interacting geographic, geopolitical, environmental, cultural, economic,...

Pituitary neuroendocrine tumors: imaging features, clinical relevance, and a proposal for standardized MRI reporting

Pituitary neuroendocrine tumors (PitNETs) are a heterogeneous group of lesions redefined in the 2022 WHO classification, emphasizing their neuroendocrine nature and biological variability. Despite advances in imaging, radiological reporting of PitNETs remains inconsistent and lac...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...