Universidad del Desarrollo

Temporal distribution of recorded indications for first revision total knee arthroplasty: a multicenter Chilean cohort of 150 patients

INTRODUCTION: /Objectives: Recorded indications for first revision total knee arthroplasty (TKA) may vary with time after the primary procedure. This study compared their distribution among early and late first revisions in a multicentre Chilean cohort. METHODS: This retrospectiv...

Beyond Words: Arts-Based Research Methods as an Intercultural Bridge for Work With Indigenous Women in Peru

This commentary examines two arts-based techniques, Image Theatre and drawing, used in a participatory project carried out in 2025 in Condorcanqui, an Amazonian province of Peru, with 12 Awajún and Wampís leaders and 12 state workers. Spanish fluency, literacy and institutional p...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Connexin46-enriched extracellular vesicles facilitate cargo delivery and promote angiogenesis

Abstract Extracellular vesicles (EVs) are constantly released from cells. Their contents vary depending on conditions and cell type, influencing their effects on recipient cells. They have been implicated in several diseases, being currently recognized as key mediators of interce...

From Classroom to Streets: The Effect of Schools on Political Participation Among Chilean Youth

During the past 20 years, students in Chile have taken center stage in several political demonstrations. In this study, we explore the effects of school-related variables on youth political participation using administrative data on school attendance during protests in October 20...

Training-transfer validation of a portable VR laparoscopic simulator: 6-DoF kinematic assessment on a common physical reference task

Portable consumer-headset virtual reality (VR) simulators can broaden access to instrumented surgical training, but their value depends on whether skills acquired in VR transfer beyond the immersive environment. We evaluated SECMA, a portable VR laparoscopic simulator, against co...

Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow

Abstract Rationale The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assesse...

Association between fluid balance, muscle strength, and muscle quality in critically ill patients: a retrospective observational study

Abstract Background Intensive Care Unit–acquired weakness (ICUAW) is a frequent complication that significantly impairs functional recovery in critically ill patients. Fluid overload during critical illness has been associated with adverse outcomes, but its relationship with peri...

Molecular overview of major salivary gland carcinomas in chilean patients: 2 case reports

Abstract Background Salivary gland tumors (SGTs) are rare neoplasms that account for 8.5 % of head and neck cancers and comprise a highly heterogeneous group of benign and malignant subtypes, according to the World Health Organization. In Chile, epidemiological and molecular data...

Earthquakes and divergent economic recovery: case studies of Chile and New Zealand

Abstract The consequences of natural disasters, such as earthquakes, are evident: death, coordination problems, destruction of infrastructure, and displacement of the population. However, according to empirical research, the impact of a natural disaster on economic activity is mi...

Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover

OBJECTIVES: To identify biological findings underlying skeletal muscle dysfunction in adults with critical illness and meta-analyze myofiber cross-sectional area and protein turnover variables. DATA SOURCES: Six databases were electronically searched from inception to January 202...

FT-IR–based strategy for Streptococcus pneumoniae serotyping using machine-learning classifiers

Rapid serotype identification of circulating Streptococcus pneumoniae is essential for both effective epidemiological surveillance and clinical management. The gold standard serotyping method (Quellung reaction) is time-consuming, labor-intensive and expensive. Fourier transform...