Universidad de Valladolid

Artificial Intelligence as a Catalyst for Cell-Based Therapies in Retinal Disease

Retinal degenerative diseases, including age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt disease, represent leading causes of irreversible vision loss worldwide, collectively affecting hundreds of millions of people. Cell-based therapies, particul...

Eating under Christian rule: isotopic evidence for food access and resilience among a medieval Muslim minority in Iberia

Muslim minorities are documented as taxpayers or legal subjects in medieval Europe, but rarely as individuals or households. This study examines carbon and nitrogen stable isotopes from 120 individuals buried at Torre Monreal, Tudela (Navarre, Spain) between the late eleventh and...

Long-Term Survival and Functional Outcomes of Scaphotrapeziotrapezoid Arthroplasty

Abstract Scaphotrapeziotrapezoid (STT) osteoarthritis is the second most common cause of wrist degeneration. Traditional surgical options, such as STT arthrodesis or distal scaphoid resection, may alter carpal kinematics or be associated with complications. Resurfacing arthroplas...

Tuning Second-Sphere Amine Basicity to Modulate Hydride Intermediates and Selectivity in Molecular Manganese Bipyridine CO2 Electroreduction

Abstract Manganese bipyridine tricarbonyl complexes represent a prominent class of molecular electrocatalysts for efficient and selective CO2-to-CO conversion. Recent efforts have sought to redirect product selectivity toward HCOOH by incorporating second-sphere amine proton rela...

Transdisciplinary Enactive Realism: Towards an Ontology of the Leib and Epistemic Translation in the Sociosanitary Ecosystem

Background: The historical fracture between biomedical positivism and social constructivism has perpetuated an epistemic schizophrenia, reducing the human body either to a molecular machine (Körper) or to a discursive epiphenomenon, thus obscuring the structural roots of illness....

SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Cohort Study Comparing Adherence and Persistence with Specific Reference to Cardiovascular Disease

Background/Objectives: Poor adherence and persistence to sodium-glucose cotransporter-2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a critical issue in the treatment of type 2 diabetes mellitus (T2DM), especially in patients with cardiovasc...

Exposure to Environmental Tobacco Smoke: a Modifiable Factor of Hospitalization and Severity of Acute Bronchiolitis

OBJECTIVE: The objective was to evaluate the associations of environmental tobacco smoke exposure with acute bronchiolitis and its severity among hospitalized children. METHODS: This case-control study with prospective follow-up was conducted at a tertiary care hospital (February...

Redistribution meets decarbonisation: Exploring universal basic income through an ecological macroeconomic integrated assessment model

The dual challenge of climate change and rising inequality calls for policies capable of delivering both ecological sustainability and social equity. Within the field of Ecological Macroeconomics (EM), integrated assessment models (IAM) with biophysical and socio-economic linkage...

Synthesis, DFT studies, and molecular docking of novel pyrazole semicarbazones targeting GPb, PPA-II, and DPP-4 enzymes

Abstract Six new phenyl-1 H -pyrazole-carbaldehyde semicarbazone derivatives ( 1 – 6 ) have been synthesized and characterized by FT-IR, NMR ( 1 H and 13 C), and mass spectrometry. NMR analysis indicated that these compounds in DMSO-d 6 exhibit a cisE isomeric form. This evidence...

Tourism Performance as a Measure of Tourism Competitiveness in Asia‐Pacific: Exploring the Determinant Effect of Level of Globalization

ABSTRACT This paper analyses the effect of globalization on tourism competitiveness in the Asia‐Pacific area. To achieve this objective, a tourism competitiveness indicator has been constructed through the information published by the World Economic Forum (WEF), in which the main...

Spatial Data Fusion and Machine Learning Bias Correction for Convection-Permitting Atmospheric Downscaling and Multi-Criteria Site Feasibility Mapping in Complex Coastal Terrains

High-resolution atmospheric modeling over topographically complex coastal zones requires multi-source spatial data fusion to bridge the scale gap between satellite-assimilated global reanalysis and localized boundary layer dynamics. This study presents a spatial data fusion frame...

One Prompt Does Not Fit All: Comparing Uniform and Adaptive Code‐Specific Prompting for Deductive Qualitative Coding With Large Language Models

ABSTRACT Background Large language models (LLMs) have demonstrated potential for (semi‐)automating the qualitative analysis of unstructured data, particularly in deductive qualitative coding using codebooks. While prior research has shown the feasibility of this technology, model...

Clostridium-based biorefineries in sugarcane bioethanol and biodiesel production: metabolic pathways, substrate diversity, and bioproduct yields

The global transition toward sustainable energy systems has intensified interest in biorefineries capable of converting renewable feedstocks and industrial residues into fuels and value-added chemicals. Bioethanol and biodiesel represent the two largest biofuel industries worldwi...

Semantic-aware decoding of covert inner speech: A multimodal EEG–EMG–audio framework

Non-invasive brain–computer interfaces (BCIs) aim to restore communication by decoding intended messages directly from neural activity, even without audible speech. However, evidence remains limited that non-invasive signals can support subject-held-out decoding of predefined sem...

Ultra-low-density neat HDPE foams via steam-assisted scCO2 foaming

High-density polyethylene (HDPE) is difficult to foam because of its high crystallinity and low melt strength, and most strategies require crosslinking, blends or fillers. Here, we investigate an additive-free route based on one-step batch foaming with supercritical CO 2 (scCO 2...

How storage conditions shape greenhouse gas emissions, physical–chemical characteristics, and pathogen fate in cattle manure

Given the large amounts of manure generated in livestock farming, evaluating the effects of aerobic and anaerobic storage on emissions and pathogen fate is essential. Accordingly, six batches of fresh cattle manure were collected over 12 months and stored for 28 days under aerobi...

Baseline performance in multi-project scheduling for SMEs: evidence from microsoft project and MPSPLib

Small and medium-sized enterprises (SMEs) often manage multiple concurrent projects with limited resources but rely on general-purpose commercial project scheduling software due to affordability and accessibility constraints. While the research community has advanced powerful heu...

Exercise-based interventions for prevention and management of deep vein thrombosis: A systematic review

ObjectiveTo evaluate the effectiveness and safety of exercise-related interventions for the prevention and management of deep vein thrombosis (DVT).Data sourcesPubMed, Web of Science, and Google Scholar were searched from inception to 31 December 2024 using terms related to exerc...

Urinary Hypaphorine as a Candidate Marker of FFQ-Derived Legume Intake Within the EAT-Lancet Framework in Free-Living Adults

Dietary assessment is affected by recall, reporting, portion-size error, and food-composition inconsistencies. Hypaphorine, a tryptophan-derived betaine alkaloid found in pulses and other foods, has been proposed as a marker of legume exposure, but its performance in free-living...

Sustained iron-nanoparticle exposure reveals concentration-dependent enhancement and inhibition during continuous hydrogen production from brewer's spent grain hydrolysate

Iron-based nanoparticles can enhance dark fermentation, but sustained-exposure effects remain unclear. This study aimed to investigate continuous supplementation with iron (III) oxide nanoparticles (FeNPs) during dark-fermentative hydrogen production from brewer's spent grain (BS...