Universidad de Navarra

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...

Systematic Mapping of Context-Specific Essential Metabolites in Cancer

Genetic minimal cut sets (gMCSs) for metabolite synthesis in human and yeast genome-scale metabolic models, supporting the paper "Metabolite essentiality in cancer cell lines predicted by genetic minimal cut sets". A gMCS is a minimal set of genes whose joint knockout blocks synt...

Rethinking primary–palliative care collaboration: insights from a mixed-methods study in a spanish region

Both specialist- and primary-level palliative care services are needed if high levels of access to palliative care are to be achieved. The Alava province in the Autonomous Community of Spain’s Basque Country is undertaking a quality improvement initiative to optimize collaboratio...

Invasive Bacterial Infections Other Than Escherichia coli and Streptococcus agalactiae in Febrile Infants Younger Than 90 Days

BACKGROUND: Invasive bacterial infections (IBIs) in febrile infants ≤90 days are mostly caused by Escherichia coli and Streptococcus agalactiae. However, data on IBIs caused by other pathogens remain limited. METHODS: We conducted a multicenter retrospective study of febrile infa...

Impact of the 2023 ACR/EULAR classification criteria on thrombotic antiphospholipid syndrome: reclassification patterns and long-term outcomes in a 419-patient cohort

The 2023 ACR/EULAR classification criteria for antiphospholipid syndrome (APS) were developed to improve specificity and to define more homogeneous research populations. However, their performance in real-world cohorts of thrombotic APS with long-term hard outcomes remains insuff...

Blood-brain barrier opening with focused ultrasound reduces neuromelanin in a non-human primate model.

Age-related accumulation of neuromelanin (NM) has been implicated in the intrinsic vulnerability of catecholaminergic neurons in Parkinson's disease. Postmortem studies in Parkinson's disease patients have revealed elevated intracellular and extracellular NM in the substantia nig...

Infections in MonumenTAL-1: a plain language summary of talquetamab treatment for relapsed/refractory multiple myeloma

Plain Language SummaryWhat is this summary about?This summary describes infection and immune cell data of participants receiving talquetamab for relapsed/refractory multiple myeloma (RRMM) in the MonumenTAL-1 study.What were the results?Almost 60% of participants receiving talque...

Trends in artificial intelligence-generated and -assisted content in comment pieces in The Lancet Regional Health, 2020–2025: a longitudinal study and citation impact analysis

Abstract Background Large language models (LLMs) are now widely used in numerous text-generation exercises. This trend raises important questions about the scientific literature and the effectiveness of editorial checks. This study aimed to measure the frequency of artificial int...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

CXCL9-driven immune rewiring and tumor-intrinsic ATR signaling inhibition restore radiotherapy response in lung cancer

Abstract Background Non-small cell lung cancer (NSCLC) accounts for ~ 85% of lung cancers and is associated with poor outcomes in advanced stages. Radiotherapy (RT) is central to NSCLC treatment, yet locoregional relapse remains frequent. Increasing evidence indicates that, beyon...

Association between choroidal structure and retinal fluid location in type 1 neovascular age-related macular degeneration

Abstract Objectives To correlate choroidal structure parameters with the presence and amount of subretinal fluid (SRF) and intraretinal fluid (IRF) in treatment-naïve neovascular age-related macular degeneration (nAMD) patients with type 1 macular neovascularisation (MNV). Method...

Territorial inequities in access to essential medicines for neglected tropical diseases in a decentralised European health system: a nationwide assessment in Spain

Abstract Background Neglected tropical diseases (NTDs) represent an increasing but often overlooked challenge for European health systems owing to international mobility, migration, travel, and climate-related changes in disease ecology. Although effective treatments exist for mo...

Alcohol consumption and cardiovascular health: balancing assumed benefits with the available evidence

1. The distinction between the well-established harms of high total alcohol intake versus purported cardiovascular benefits of small amounts of wine seems crucial [1–3]. Ethanol at high doses is a ...

From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME

Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) are leading causes of visual impairment and require long-term intravitreal anti-vascular endothelial growth factor (VEGF) therapy. However, treatment burden and suboptimal real-world outcomes rem...

Undesired body orientations in competitive pedestrian evacuations

We report time-resolved experimental measurements of human body orientation in extremely dense crowds during highly competitive evacuations. By comparing different scenarios, we find that as competitiveness increases and contact forces among pedestrians build up, orientational or...

Astrocytic PI3Kα controls synaptic plasticity and cognitive function via serine metabolism

Astrocytes modulate neuronal activity by gliotransmission and through metabolic regulation, yet the relationship between these functions remains poorly understood. Here we show that phosphatidylinositol 3-kinase (PI3K) signaling in astrocytes controls synaptic plasticity and memo...

Sustainable Synthesis of Faujasite-Type Zeolites Synthesized from Rice Husk for Hg2+ Removal from Aqueous Solutions: Adsorption Performance, Mechanistic Insights, and Environmental Safety Assessment

Rice husk, an abundant agro-industrial by-product rich in SiO2, represents a promising precursor for the sustainable synthesis of zeolites. In this study, rice husk ash was used to synthesize faujasite-type X and faujasite-type Y, and their performance for Hg2+ removal from aqueo...

Prognostic value of Amyloid PET in Real-World Amnestic MCI: Influence of reader experience and interpretation method

PURPOSE: This study assessed the prognostic value and inter-/intra-observer reliability of three amyloid PET interpretation methods-conventional visual reading, assisted visual interpretation and standardized uptake value ratio (SUVR)-based quantification-for predicting conversio...

Geopolitical Risks and Fossil Fuel Returns during the Last Four Decades

Abstract This paper empirically investigates the directional predictability of geopolitical risks (distinguishing between geopolitical acts and threats) on the returns of fossil fuels (crude oil, coal, and natural gas) over the last four decades, from January 1984 to February 202...

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...