Universidad de Montevideo

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Nicotinamide adenine dinucleotide (NAD) is a metabolic cofactor regulating energy metabolism, epigenetics, DNA repair, and signaling. Although NAD declines with vitamin B3 deficiency, disease, and aging, systemic consequences of chronic depletion remain unclear. Here, we characte...

Electron transfer in electrocatalytic reactions: effective symmetry factors

Abstract The evaluation of electron transfer kinetics at electrochemical interfaces plays a fundamental role in optimizing the efficiency of electrocatalytic reactions of technological interest. Different approaches to this topic arose from the analysis of experimental data that...

Improving access to new technologies: An experiment with Kenyan input sellers

Abstract Agrodealers play a critical role in rural economies, selling essential inputs for agricultural production, stocking new products, and providing farmers with technical advice. However, uncertainty can discourage them from stocking newer, less familiar products, limiting t...

Sensorimotor teleology and goal-directedness. An organismic framework for normative behaviour

Abstract Teleosemantics explains meaning by appealing to the biological norms that make error possible, but most work in the field still anchors those norms in evolutionary “selected-effect” functions. We develop an organismic alternative grounded in the self-maintenance of auton...

Geophysical modeling in a drainage basin with a gold geochemical anomaly, Cerro da Cria Region, Vila Nova do Sul, Rio Grande do Sul (Brazil)

Gold plays a central role in the global economy as a store of value, a strategic asset, and an important raw material for industrial and technological applications. In mineral exploration, geochemical prospecting allows the delineation of anomalous drainage basins and the identif...

Salivary Cobalt, Nickel, Chromium and Titanium After Fixed Orthodontic Appliance Removal: A 3-Month Pilot Longitudinal Study

Objective: Our objective was to determine the salivary levels of cobalt, nickel, chromium, and titanium ions at the end of fixed orthodontic treatment and during the post-removal period (1 and 3 months after removal of the fixed appliance). Methods: This pilot longitudinal study...