Universidad de La Frontera

Intelligent Systems for Space Conditioning and Shading in Buildings: A Systematic Review of Artificial Intelligence Techniques and Their Energy Impact

Artificial intelligence (AI) is increasingly applied to heating, ventilation, and air-conditioning (HVAC) control, whereas solar-radiation management still relies mainly on reactive strategies; whether AI capabilities validated in HVAC could be transferred to solar control has no...

Development and Field Evaluation of a Prototype Bacterial Inoculant for Cuban Rice Under Reduced Nitrogen Fertilization

Rice is a priority crop in Cuba, and bacterial inoculants could help sustain productivity under reduced mineral fertilizer inputs. However, evidence describing the main stages involved in developing these bioproducts in the country remains limited. This study aimed to evaluate th...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

Overweight, Obesity, and Musculoskeletal Symptom Burden in Chile: A Population-Based Cross-Sectional Study

Background/Objectives: Musculoskeletal symptoms (MSS) are among the leading causes of pain and functional limitation worldwide, yet population-level evidence linking excess body weight to MSS in Latin America remains scarce. This study examined the association between body mass i...

Efficacy and Safety of EG12014 (Biosimilar Trastuzumab) Compared to Reference Trastuzumab in HER2-Positive Early Breast Cancer: A Phase III Randomized Study

Trastuzumab biosimilar EG12014 (Herwenda ® ; EirGenix/Sandoz) was approved by the European Medicines Agency (EMA) in 2023. We aim to demonstrate equivalent efficacy, and to compare safety, immunogenicity, and pharmacokinetic (PK) profiles, of EG12014 and reference trastuzumab (re...

Neoliberal housing and the health–poverty nexus: mapping of evidence using a systematic framework synthesis from Argentina and Chile

This systematic review responds to a critical gap in housing and health literature by examining how neoliberal housing policies impact low-income populations in Argentina and Chile. While existing reviews often link housing conditions to health outcomes, few consider the structur...

‘I wanted the whole world to know … it’s just part of who I am’: sexual identity development and management among lesbian, gay and bisexual Chilean adults

This study explored how lesbian, gay, and bisexual adults in La Araucanía, a region in southern Chile, developed and managed their sexual identities. Twelve adults aged 30 to 41, who came of age during a time of limited LGBTQ+ visibility and legal recognition, participated in sem...

Habitat Complexity and Seasonal Variation Factors Shape the Polychaete Assemblies Associated with the Holdfast of Lessonia berteroana

Lessonia berteroana is a structuring macroalga that houses a high diversity of benthic invertebrates in southeastern Pacific rocky ecosystems. The present study assessed the diversity and structure of the community of polychaetes associated with the holdfast of L. berteroana at t...

Evaluation of the Potential Hypoglycemic and Neuroprotective Effects of Rosehip Fruit

Rosehip fruit (Rosa spp.) has sparked growing scientific interest due to its high content of bioactive compounds, which give it significant therapeutic potential. In a context where nutritional issues like obesity and type 2 diabetes continue to increase worldwide, the search for...

Topology-Driven Compression and Energy Absorption of PLA-Lattice-Reinforced Mortar

The design of cellular architectures based on topology offers a promising strategy for tailoring the mechanical performance of cementitious composites without altering the matrix composition. However, the influence of the topological transition from re-entrant auxetic structures...

Early-Life Stress Programs a Vulnerable Renal Phenotype Under Metabolic Challenge in a Murine Model

Early-life stress and post-weaning exposure to a high-fat diet (HFD) have been independently associated with renal abnormalities; however, little is known about how these stressors interact to increase renal susceptibility to subsequent metabolic challenges. Therefore, this study...

A Feature Model-Based Reference Architecture for Data Lake Ingestion: A Variability Management Approach

The growth of big data ecosystems has shifted the classical paradigm of selective storage toward an approach that preserves large volumes of heterogeneous data for subsequent exploitation, thereby strengthening the adoption of repositories such as data warehouses and, particularl...

Evidence-Based Quality Assurance in Initial Teacher Education and Educational Sustainability

Quality assurance in Initial Teacher Education (ITE) has evolved from compliance-oriented approaches toward more comprehensive frameworks emphasizing continuous improvement, evidence-informed decision-making, and educational sustainability. Nevertheless, across Latin America, per...

From Data Quality to Quality of Agentic Data Use: A Conceptual Framework for Agentic Data Engineering

Large language models and AI agents are extending data-engineering automation beyond isolated artifact generation toward end-to-end processes in which agents interpret requirements, select data, generate transformations, invoke tools, validate results, and communicate analytical...

Development and validation of a time use questionnaire for women in family farming

Abstract This study develops and validates the Time‑Use Questionnaire for Women in Family Farming (TUQ‑FF), a context‑specific instrument designed to measure productive, domestic, caregiving, and social‑participation activities among rural women in Chile. Drawing on international...

Spanish version of the personal experience of aging scale: psychometric analyses from classical and network psychometrics approaches in a Chilean sample

Abstract Background How people experience aging is linked to health, well-being, and engagement in later life, but Spanish-language measures for capture self-perceptions of aging in Latin America remain limited. Objective To adapt the Personal Experience of Aging Scale (PEAS) int...

Ocular manifestations of expanded dengue syndrome: a systematic review with meta-analysis

Ocular manifestations are under-recognized complications of expanded dengue syndrome, with no robust frequency estimates available. A systematic review was conducted following PRISMA guidelines. Primary studies reporting the frequency of ocular manifestations consistent with expa...

Viridicatin from the Antarctic Fungus Penicillium sp. Protects Human Microglia and Patient-Derived Peripheral Immune Cells Against Oxidative Stress

Neurodegenerative diseases remain a major therapeutic challenge, with oxidative stress playing a central role in central and peripheral immune system dysfunction that leads to neuronal loss. Natural products from extreme environments represent an underexplored source of neuroprot...

Slowly rotating condensate dark stars beyond the mean-field approximation

Abstract We investigate rotational properties and universal relations of slowly rotating Bose–Einstein condensate dark stars in the context of General Relativity, both at the mean-field level and when the leading beyond-mean-field Lee–Huang–Yang correction is retained self-consis...

Beyond bactericidal surfaces: interfacial selectivity as a design principle for implant biomaterials

Within seconds of placement, an adsorbed conditioning film replaces the implant's manufactured substrate and becomes the true interface host cells and microorganisms encounter. Conventional strategies engineered to kill or suppress bacteria therefore act on an interface neither p...