Universidad de Guanajuato

How to Train Your Chatbot: Information‐Theoretic Foundations of Diagnostic Questioning in Inborn Errors of Immunity

BACKGROUND: Navigating the more than 550 inborn errors of immunity (IEI) requires efficient diagnostic reasoning. Information theory suggests questions should be prioritized by their capacity to reduce diagnostic uncertainty (entropy); yet whether experts or large language models...

Synthesis of Spiro-Bridged 3,4-Dihydrocoumarins Through an Organocatalytic Cascade Sequence Diels–Alder/Nucleophilic Ring Closing

3,4-dihydrocoumarins and spiro compounds constitute an important class of privileged frameworks present in a wide variety of natural and synthetic molecules with diverse applications. In this study, we developed an organocatalytic methodology for the construction of complex and d...

Oleogels and Related Structured-Lipid Systems as Dual-Function Ingredients in Meat Products: Saturated Fat Replacement and Bioactive Delivery

Oleogels, in which liquid oils are structured into semi-solid matrices by oleogelators, have been widely investigated as animal fat replacers in meat products, where they lower saturated fatty acid content while helping preserve texture, structure, and emulsion stability. The rep...

Synthesis, antimicrobial evaluation, and computational investigation of novel thiazole-carbamate hybrids as dual antibacterial and antifungal agents

A new series of thiazole-based carbamate hybrids was synthesized to develop improved antibacterial and antifungal agents. The compounds were prepared by reacting aminothiazole with various chloroformates, followed by hydrolysis to obtain carbamate acids, which were then coupled w...

Evaluation of Residential Satisfaction in Mexico: Creation and Validation of a Measure Instrument / Evaluación de la satisfacción residencial en México: creación y validación de un instrumento de medida

Accurately measuring residential satisfaction is important when it comes to guiding architectural design strategies that improve people’s quality of life in line with their needs. The aim of this study was to create and validate a specific instrument to measure residential satisf...