Universidad Católica Andrés Bello

Lifestyle Medicine Competencies in Women’s Health: Consensus-Based Standards From the International Board of Lifestyle Medicine

Lifestyle medicine (LM) takes an evidence-based approach to the prevention and management of many conditions affecting women; however, no dedicated competency framework currently guides its application across the life span. We aimed to develop a comprehensive set of core competen...

Unraveling theMolecular Basis of NSD3 AllostericActivation Driven by Nucleosome Binding: A Multiscale MD and QM/MMApproach

Abstract Nuclear receptor-binding SET domain 3 (NSD3) is a methyltransferase responsible for mono- and di-methylation of histone H3 lysine 36, whose hyperactivation is linked to accelerated cancer cell proliferation. Isolated NSD3 is autoinhibited due to a conformation that preve...