Universidad Cardenal Herrera CEU

Artificial intelligence for clinical data extraction from EHRs in breast cancer trials: the MIRROR study

Manual data entry and curation is the most used method of data collection for real world evidence and clinical trials but is a time-consuming task associated with significant human effort and transcription mistakes. MIRROR is a retrospective study that compared manual data captur...

Prognostic Significance of p53 Immunohistochemical Expression and Molecular Characterization of TP53 Variants in Triple-Negative Breast Cancer After Neoadjuvant Chemotherapy

Background: The prognostic significance of p53 immunohistochemical expression in triple-negative breast cancer (TNBC) remains controversial, particularly following neoadjuvant chemotherapy (NAC). The relationship between p53 immunohistochemical expression, TP53 sequence variants,...

Sexual dimorphism shapes the plasma metabolome of the endangered Iberian lynx

Sexual dimorphism is a key but still incompletely resolved determinant of mammalian systemic metabolism, particularly in endangered species where physiological organization remains poorly characterized. Here, we integrate untargeted plasma metabolomics to dissect hierarchical det...

In vitro evaluation of pH, calcium ion release and interfacial characterization of calcium silicate–based and epoxy resin–based sealers

Abstract This in vitro study evaluated the physicochemical properties and interfacial behavior of four calcium silicate–based sealers (CSBS) compared to an epoxy resin–based sealer. Specimens were prepared under standardized conditions, and pH and calcium (Ca 2+ ) ion release wer...

Autologous Platelet-Rich Plasma–Enriched Chondral Matrix Implantation Improves Cartilage Repair in an Ovine Model: A Magnetic Resonance Assessment Using the MOCART 2.0 Scoring System

BACKGROUND: Articular cartilage defects exhibit a limited intrinsic regenerative capacity and continue to represent a significant challenge in sports medicine, frequently progressing to degenerative joint disease if left untreated. PURPOSE: To assess cartilage repair after autolo...

Longitudinal comparison of animal and environmental microbiota, Coxiella burnetii detection frequency, and seroconversion in two goat herds following a Q fever outbreak and whole-herd vaccination

Two goat herds were longitudinally monitored following the implementation of a whole-herd vaccination protocol after a Q fever outbreak. Faecal, milk, vaginal, preputial, nasopharyngeal, environmental (qPCR and 16 S rRNA ), and blood samples (serology) were analysed. Before vacci...

The effect of partial replacement of soybean oil with insect fats on dietary short-term preference in laying hens

Assessment of the acceptance of novel feed ingredients provides valuable insights into their potential integration into practical animal feed formulations. However, despite growing interest in insect-derived feed ingredients, information on the short-term palatability of insect f...

Fast arbitrary qutrit gates for NV centers in the low-field regime

Abstract The ground state of the negatively charged NV center forms a spin–1 manifold providing a versatile platform for sensing and information processing. Here we present a scheme for implementing fast arbitrary qutrit gates in the low–field regime using monochromatic microwave...

Acute Effects of Contract–Relax PNF With and Without Neuromuscular Electrical Stimulation on Hamstring Flexibility and Jump Performance in Adolescent Soccer Players: A Randomized Controlled Trial

Background The additional value of neuromuscular electrical stimulation (NMES) during contract–relax proprioceptive neuromuscular facilitation (PNF-CR) stretching remains unclear, particularly in adolescent athletes. It is also unknown whether combining PNF-CR with motor-threshol...

Intraoperative monitoring and anaesthetic complications in horses: A secondary analysis of the CEPEF4 multicentre cohort

Abstract Background CEPEF4 provides the most comprehensive contemporary dataset on perianaesthetic risk in horses. Intraoperative complications, monitoring and American Society of Anesthesiologists (ASA)‐stratified associations with death remain incompletely described. Objectives...

Comparing the effect of faecal microbiota and faecal filtrate transplantations on intestinal health in weaned piglets

<title>Abstract</title> Background Faecal microbiota transplantation (FMT) and faecal filtrate transplantation (FFT) have emerged as promising methods to prevent intestinal dysbiosis and diarrhoea in piglets after weaning. The aim of this study was to compare the effects of FMT a...

Ochratoxin A Toxicity Research in In Vitro and In Vivo Experimental Settings: A Cross-Software Bibliometric and Science-Mapping Study

Background: Ochratoxin A (OTA) is a widespread mycotoxin with well-established nephrotoxic, immunotoxic, and carcinogenic properties. Despite decades of research, the structure, thematic evolution, and emerging directions of the scientific literature on OTA toxicity remain incomp...

Seasonal modulation of platelet indices in mares

Platelet indices provide valuable information on platelet activation, heterogeneity, and production kinetics, yet their physiological variability remains poorly characterized in horses. Although seasonal changes in platelet count have been described, the seasonal modulation of de...