Universidad Alfonso X el Sabio

Pacing and effort distribution in Hyrox® PRO athletes: differences by sex and performance level

Hyrox ® has rapidly grown into one of the most popular High-Intensity Functional Training (HIFT) competitions, combining running and strength-based stations in a comparatively standardised format. Although pacing and effort distribution are established determinants of performance...

A preoperative nomogram to predict axillary lymph node involvement in clinically node-negative HR+/HER2- breast cancer

Abstract Objective To develop a preoperative nomogram to predict axillary lymph node involvement in clinically node-negative hormone receptor-positive/HER2-negative (HR+/HER2-) breast cancer. Materials and methods We analyzed a retrospective cohort of consecutive patients with in...

Validating Type 2 Diabetes Diagnoses Across the Madrid Hospital Network: Evidence for Secondary Use of the CMBD in the European Health Data Space

Background/Objectives: Hospital discharge data are increasingly reused for research and within health data spaces, but their value depends on accurate diagnostic coding. The validity of type 2 diabetes mellitus (T2DM) coding in the Spanish hospital discharge database (CMBD) had n...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Cardiometabolic multimorbidity phenotypes and their associations with functional and cognitive outcomes in older Chilean adults: findings from the Chilean national health survey

Abstract Background Multimorbidity is highly prevalent among older adults and is associated with functional decline, disability, cognitive impairment, and increased healthcare burden. However, traditional disease-count approaches may fail to capture the heterogeneity of multimorb...

Coach and athlete perceptions of internal training load in U-16 male water polo: an exploratory single-team mixed-methods case study

The coach-player relationship plays a role in determining athletes’ performance and development. Monitoring internal training load (ITL) through the session rating of perceived exertion (sRPE) scale offers an accessible way to assess exertion, but discrepancies often arise betwee...

Educational and Professional Development Interventions to Strengthen Empathy, Compassion, and Relational Care Among Healthcare Professionals: A Systematic Review

Humanized healthcare depends on professionals’ capacity to communicate empathically, respond compassionately, and establish therapeutic relationships. This globally focused systematic review aimed to synthesize comparative evidence on educational and professional development inte...

Spatial Variability and Magnitude of Soil Erosion in Vineyards Across Spain: Insights from Standardized ISUM Measurements

Soil erosion and sediment redistribution in vineyards often exceed tolerable thresholds, but comparative field measurements across regions remain limited because studies use different methods and sampling designs. This study assesses soil redistribution in vineyards using a commo...

Validation of plasma core biomarkers of Alzheimer's disease: A multicenter study in usual practice conditions

Background The new anti-amyloid therapies have brought the challenge of early and feasible identification of Alzheimer's disease (AD). Plasma biomarkers are promising tools, but real-world evidence remains limited. Objective We aimed to evaluate the diagnostic performance of plas...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

Use of the STRYD® Power Meter and Its Metrics in Trained Runners: A Systematic Review

The STRYD® power meter has been used by runners and running coaches in recent years. The data it provides may offer useful information for training monitoring and performance assessment. Accordingly, this systematic review identifies and analyzes the use of the main parameters pr...

Disruptive Behaviour Disorders: Parent-Focused vs. Multicomponent Interventions. A Systematic Review / Trastornos de comportamiento disruptivo: intervenciones centradas en los padres frente a intervenciones multicomponente. Una revisión sistemática

Background: disruptive behaviour represents one of the main reasons for consultation in the paediatric and juvenile population and is associated with high functional impairment that may extend into adulthood. Although evidence-based treatments with moderate effects are available,...

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

Abstract Background Myeloid cells orchestrate vascular inflammation through transcriptional programs that regulate their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, understanding of the transcriptional r...

Optimized technique for experimental multivisceral transplantation

Background There has been a shift toward combined liver-intestine and multivisceral transplantation (MVT), whereas isolated intestinal transplantation has taken a backseat, mainly because of its higher rejection rates. Despite this, experimental models tend to focus on intestinal...

Characterization and treatment of polymicrobial biofilms in prosthetic joint infections

Abstract Prosthetic joint infections are complex and associated with high economic and social costs. Polymicrobial cases remain poorly understood, particularly regarding bacterial interactions and antibiotic response within mixed-species biofilms. We introduce two approaches for...

Exploring Nursing Team Perceptions of Sleep in Critically Ill Pediatric Patients: A Mixed-Methods Study

Objective: To explore nursing team perceptions of sleep and sleep-disrupting factors in critically ill pediatric patients. Methodology: Convergent mixed-methods study comprising an exploratory qualitative and descriptive cross-sectional quantitative. For the qualitative component...