Unity Health System

Cardiovascular Manifestations of Cystic Fibrosis

Cystic fibrosis (CF) has undergone a remarkable transformation from a fatal childhood disease to a chronic adult condition, with a median predicted survival now exceeding 50 years following the introduction of highly effective CFTR modulator therapy (HEMT). This demographic shift...

Is Immune Homeostatic Competence a Distinct Capacity? A Falsifiable Test for a Sixth Determinant of Functional Reserve

A functional reserve framework for human aging proposed five modifiable physiological capacities organized around a coupled mitochondrial—epigenetic axis and excluded immune competence because its major age-related failures were interpreted as mediated through the other capacitie...