United Therapeutics (United States)

Hybrid Respiratory Dialysis for Ultra-Low Blood-Flow Extracorporeal CO2 Removal

Extracorporeal carbon dioxide removal (ECCO 2 R) has emerged as a promising therapeutic avenue to address the challenges of CO 2 accumulation during chronic obstructive pulmonary disease (COPD) exacerbations. Current COPD exacerbation interventions rely on invasive mechanical ven...

A mechanistic perspective of RNA‑LNP instability and characterization toolbox

LNPs are proven to be effective nanocarriers for delivering nucleic acid in vivo. The US FDA approval of multiple LNP‑based drug products catalyzed multiple clinical studies across disease indications covering various RNA modalities. However, the stability of LNPs has been a long...