Unité de Glycobiologie Structurale et Fonctionnelle

An Integrated Workflow for Real-Time Chemoenzymatic CMP-Sialic Acid Preparation and a Bioorthogonal Microplate Sialyltransferase Assay (MPSA)

Abstract Sialylation at the terminal ends of cell-surface glycoproteins and glycolipids plays a pivotal role in dictating cellular interactions, human health, and pathological processes. This crucial modification is mediated by a family of twenty distinct human sialyltransferases...

A trick of the tail: How electrostatics helps a DNA repair enzyme to localize on nucleosomes

Electrostatic interactions are key to the recognition processes of proteins and DNA and have been previously documented for the action of repair enzymes. Uracil-DNA glycosylase (UDG) is the first in a sequence of enzymes that act in the base-excision repair process and whose task...