Union Hospital

P1.137. Baseline Skeletal Muscle Depletion Stratifies Treatment Feasibility and Survival in Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Immunochemotherapy

Abstract Topic Esophageal Cancer: Other Background Physiological reserve plays a pivotal role in determining the capacity of patients to tolerate intensive multimodal therapy. In locally advanced esophageal squamous cell carcinoma (ESCC), neoadjuvant immunochemotherapy (nICT) has...

Nuciferine-Loaded Lipid Nanoparticle Microneedles Alleviate Intervertebral Disc Degeneration by Restoring Nucleus Pulposus Cell Homeostasis

Background/Objectives: Intervertebral disc degeneration (IDD) is a major cause of chronic low back pain and disability. Nuciferine, a natural alkaloid with mitochondrial protective activity, shows therapeutic potential for IDD. However, the avascular nature of intervertebral disc...

Cross-KingdommiR5054 Delivery via Polygonum cuspidatum -Derived Nanoparticles Enhances Burn Wound Healingby Regulating Microvascular Environment

Abstract Deep partial-thickness burns are characterized by a self-perpetuating cycle of oxidative stress and inflammation that severely impedes healing. Here, we identified Polygonum cuspidatum-derived nanoparticles (PDNs) as a multifaceted nanotherapeutic that breaks this pathog...