Union Hospital

External validation and comparative performance of four risk scores for acute kidney injury in critically ill adults

Background Several parsimonious scores predict acute kidney injury (AKI), but their comparative performance in critically ill adults is uncertain. We hypothesized that the ICU-derived UCSD-Mayo score would show higher discrimination than three scores developed in broader acute-ca...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

An i-Motif Conformational Transition Synergizing with pH-Responsive Reduced Graphene Oxide Field-Effect Transistor for Urease Activity Sensing

Abstract Urease serves as a key diagnostic biomarker, whose abnormal activity is closely associated with oral diseases such as caries and periodontitis. However, detecting trace urease in saliva remains technically challenging. In this work, we report for the first time a C4-rGO-...

P1.137. Baseline Skeletal Muscle Depletion Stratifies Treatment Feasibility and Survival in Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Immunochemotherapy

Abstract Topic Esophageal Cancer: Other Background Physiological reserve plays a pivotal role in determining the capacity of patients to tolerate intensive multimodal therapy. In locally advanced esophageal squamous cell carcinoma (ESCC), neoadjuvant immunochemotherapy (nICT) has...

Nuciferine-Loaded Lipid Nanoparticle Microneedles Alleviate Intervertebral Disc Degeneration by Restoring Nucleus Pulposus Cell Homeostasis

Background/Objectives: Intervertebral disc degeneration (IDD) is a major cause of chronic low back pain and disability. Nuciferine, a natural alkaloid with mitochondrial protective activity, shows therapeutic potential for IDD. However, the avascular nature of intervertebral disc...

Cross-KingdommiR5054 Delivery via Polygonum cuspidatum -Derived Nanoparticles Enhances Burn Wound Healingby Regulating Microvascular Environment

Abstract Deep partial-thickness burns are characterized by a self-perpetuating cycle of oxidative stress and inflammation that severely impedes healing. Here, we identified Polygonum cuspidatum-derived nanoparticles (PDNs) as a multifaceted nanotherapeutic that breaks this pathog...