Unidade Local de Saúde de Entre Douro e Vouga

Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...

Central nervous system manifestations in hereditary transthyretin amyloidosis: a cross-sectional study with 151 patients

Abstract Background Central nervous system (CNS) dysfunction is increasingly recognized in hereditary transthyretin (ATTRv) amyloidosis. We aimed to characterize CNS manifestations and assess associations with clinical variables and plasma neurofilament light chain (NfL), using h...