UConn Health

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

Abstract Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5’ → 3’ alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA th...

Impact of hospital safety culture and workplace sexual harassment on turnover intention of nursing professionals in Upper East Region, Ghana

Abstract Background The global nursing professionals’ shortfall is alarming, reaching 4.81 million by 2030, with Africa and South-East Asia disproportionately affected. While improved organizational safety culture promotes worker retention, unsafe work environments, including sex...

A “Suture Staple” Knotless Anchor Technique for Fixation of Tibial Tubercle Avulsion Fractures in Pediatric Patients

Abstract Tibial tubercle fractures are rare injuries most commonly seen in the pediatric population; more specifically the adolescent male population towards the end of peak longitudinal growth. Typically, tibial tubercle fractures are fixed with cannulated screws. However, there...

Graded oxidation state calcium phosphate graphene oxide modulates the mechanical and biological behavior of bone matrices

Calcium phosphate graphene (CaPG) is a promising reinforcement for polymeric bone matrices, yet the impact of graphene oxide (GO) oxidation on CaPG chemistry and matrix performance remains unclear. Our previous work demonstrated that 5 wt% CaPG provides optimal mechanical and bio...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...

Red Blood Cell Distribution Width Is Associated With Functional Outcomes Following Surgery for Hip Fracture

BACKGROUND: Elevated red blood cell distribution width (RDW) is increasingly found to be associated with adverse health outcomes in older adults. We leveraged a randomized clinical trial that was investigating responses to supervised exercise (EX) with or without a topical testos...