UConn Health

Vascular device practices in extremely preterm infants: an international cross-sectional survey

Abstract Objective To explore global practices in vascular device selection, securement, and monitoring for extremely preterm infants, and to assess regional variation. Study design A web-based cross-sectional survey was completed by one respondent per neonatal unit. Result We re...

Undernutrition enhances host attractiveness to mosquitoes and transmission of mosquito-borne diseases

Undernutrition is prevalent in regions affected by mosquito-borne diseases. Understanding how insufficient nutrition affects the transmission of mosquito-borne pathogens is critical for combating these diseases. In this study, we found that undernourished mice were more attractiv...

Presumptive Coverage Policies and Workers’ Compensation of Post‐Traumatic Stress Disorder and Other Mental Health Conditions: A Retrospective Time‐Series Study in Canada 2001–2019

BACKGROUND: The impact of presumptive coverage policies for work-related mental health disorders has not been extensively studied to date. Using data from the Association of Workers' Compensation Boards of Canada (AWCBC), our objectives were to describe the evolution of compensat...

Deciphering the development of synovial joints in the limbs: Recent discoveries and clinical implications

Abstract The synovial joints are essential for skeletal function and dexterity and do so by virtue of their components and structure. The capsule protects and insulates the joint from the surrounding environment, articular cartilage provides mechanical resilience and endurance, t...

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

Abstract Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5’ → 3’ alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA th...

Impact of hospital safety culture and workplace sexual harassment on turnover intention of nursing professionals in Upper East Region, Ghana

Abstract Background The global nursing professionals’ shortfall is alarming, reaching 4.81 million by 2030, with Africa and South-East Asia disproportionately affected. While improved organizational safety culture promotes worker retention, unsafe work environments, including sex...

Graded oxidation state calcium phosphate graphene oxide modulates the mechanical and biological behavior of bone matrices

Calcium phosphate graphene (CaPG) is a promising reinforcement for polymeric bone matrices, yet the impact of graphene oxide (GO) oxidation on CaPG chemistry and matrix performance remains unclear. Our previous work demonstrated that 5 wt% CaPG provides optimal mechanical and bio...

A “Suture Staple” Knotless Anchor Technique for Fixation of Tibial Tubercle Avulsion Fractures in Pediatric Patients

Abstract Tibial tubercle fractures are rare injuries most commonly seen in the pediatric population; more specifically the adolescent male population towards the end of peak longitudinal growth. Typically, tibial tubercle fractures are fixed with cannulated screws. However, there...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...

Red Blood Cell Distribution Width Is Associated With Functional Outcomes Following Surgery for Hip Fracture

BACKGROUND: Elevated red blood cell distribution width (RDW) is increasingly found to be associated with adverse health outcomes in older adults. We leveraged a randomized clinical trial that was investigating responses to supervised exercise (EX) with or without a topical testos...