Tzu Chi Foundation

Soluble N-terminal EphA2 fragment as a diagnostic biomarker and functional mediator of tumor progression in triple-negative breast cancer

Triple-negative breast cancer (TNBC) lacks reliable biomarkers for early detection and remains a highly aggressive disease. Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase frequently overexpressed in advanced cancers, undergoes MMP14-mediated cleavage that releases s...

Development of multiplex real-time polymerase chain reaction assay for the detection of leukemia-associated translocation genes

A BSTRACT Objective: Leukemia diagnosis involves diverse methods, including cytomorphology, flow cytometry, cytogenetics, and molecular diagnostics. While cytogenetics plays an indispensable role, it is limited by a high false-negative rate. In contrast, molecular diagnostics, su...

Development and psychometric validation of the medical humanistic care scale

A BSTRACT Objectives: This study aimed to develop and validate the “Medical Humanistic Care Scale” (MHCS), a novel multidimensional instrument tailored to the Taiwanese healthcare education context. The scale addresses the limitations of existing tools by integrating social, inst...

Phytochemicals Modulating Receptor Tyrosine Kinase Signaling Networks in Endometriosis

Endometriosis is a chronic, estrogen-dependent inflammatory condition that is marked by the growth of lesions outside the uterus, along with angiogenesis, fibrosis, immune dysregulation, and pain sensitization. There is now growing evidence that receptor tyrosine kinase (RTK) sig...

The effectiveness of resistance training for patients with degenerative arthritis after total joint arthroplasty: a pilot randomized controlled study

This study aimed to examine the effects of a volume-progressive staged bilateral resistance training program on lower limb muscular endurance, balance performance, pain intensity, and quality of life among patients with osteoarthritis following total joint arthroplasty (total kne...

Atypical CTPA contrast timing revealing a suspected right-to-left shunt in a patient with advanced COPD and concurrent pulmonary malignancy

Hypoxemia in chronic obstructive pulmonary disease (COPD) typically arises from ventilation-perfusion (V/Q) mismatch. However, refractory hypoxemia should raise concern for alternative mechanisms, such as intracardiac shunting. This report describes a rare presentation where a ca...