Turku Centre for Computer Science

Eco-evolutionary dynamics and environmental detoxification jointly shape bacterial community response to antibiotic perturbation

Microbial communities frequently encounter recurrent antibiotic disturbance, yet how ecological, evolutionary, and environmental processes jointly shape community responses remains unresolved. Here, we use priming to describe the history-dependent effect whereby prior exposure al...

Pharmacokinetics and efficacy of tank water-administered BRAF-inhibitor dabrafenib in a zebrafish melanoma model

Zebrafish models are widely used to study BRAF-mutant melanoma biology. However, long-term treatment of adult fish with small molecule BRAF inhibitors remains challenging, and pharmacokinetic data to inform rational dosing strategies are largely lacking for most small molecules i...

Component-Resolved CFD-Based Assessment of Surface-Element Effects on Local Wind and Turbulence in a Coastal Harbor

Abstract Accurate quantitative assessment of near-surface wind and turbulence in coastal harbors remains challenging because terrain, vegetation, and built structures interact in a direction-dependent manner and are often treated using lumped or simplified surface representations...

Prediction of platinum-based neoadjuvant chemotherapy response in muscle-invasive bladder cancer using a multifaceted approach

Abstract Radical cystectomy (RC), preceded by platinum-based neoadjuvant chemotherapy (NAC), is recommended for eligible patients with muscle-invasive bladder cancer (MIBC). Although NAC improves survival, many patients do not respond; in non-responders, it may delay surgery and...

The Invisible Web: Linking Diet and Gut Microbiota Across Time and Space in Odonates

Abstract The complex relationship between insects and their gut microbiota has become a central theme in host–microbe ecology, revealing profound effects on host fitness and interactions. Yet, how gut microbial communities—and their primary determinant, diet—vary across space and...