Tunis El Manar University

Taguchi-Optimized Green Synthesis of a Novel Nickel-bis-thiazoline Complex: A Bifunctional Platform for Sustainable Ullmann-type N-Arylation and Antibacterial Applications

A novel bis-thiazoline ligand and its nickel(II) complex were synthesized via an environmentally benign and mild protocol.Synthesis parameters were systematically optimized using the Taguchi Design of Experiments (DoE), achieving high yields (> 98%) and ensuring a scalable, repro...

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Implementing and assessing competency-based education in low-resource environments: Insights from the Tunisian experience

Competency-Based Education is increasingly promoted in higher education to strengthen competency development and alignment with professional demands, yet its implementation remains challenging in resource-constrained contexts. This study explores how CBE is adapted in Tunisian hi...

Circadian and ultradian locomotor activity rhythms in the coastal dune beetle Pimelia depressa (Coleoptera: Tenebrionidae) from Rimel, Tunisia

Tenebrionidae beetles are a conspicuous component of arid and semi-arid environments. This study investigated locomotor activity rhythms in male Pimelia depressa collected from the coastal sandy dunes of Rimel Beach, Bizerte, north-eastern Tunisia. Locomotor activity was monitore...

Yellow‐Green Fluorescence in Sebaceous Carcinoma Under Ultraviolet‐Induced Fluorescence Dermoscopy

Paweł Pietkiewicz is the President of the Polish Dermatoscopy Group and the National Representative (Poland) of the International Dermoscopy Society. He is an adviser for HEINE Optotechnik GmbH & Co. KG; he has received honoraria from HEINE Optotechnik GmbH & Co. KG, speaker fees...

microRNA and Regulatory Networks of Human Macrophage During Leishmania major In Vitro Infection

Leishmania (L.) major modulates host microRNA (miR) expression to promote intracellular survival, yet the roles of specific miRs during early infection of human macrophages remain poorly defined. We investigated the dynamic regulation of miR-21-5p and miR-146a-5p in THP-1-derived...

Neuropsychiatry genetics in Africa

Across Africa, rising mental health needs coincide with rapid advances in genomics, digital health and continental policy reform. Yet research into the genetic, environmental and social determinants of neuropsychiatric illness remains sparse and underfunded. This review argues th...

Synthesis, design and integrated in vitro/in silico assessment of novel cyano-amide derivatives

A novel and an efficient synthesis of a series of cyano-amide derivatives 3a-h was achieved via solvent-free reaction of benzylcyanide derivatives 1 with isocyanate derivatives 2 at room temperature. The produced components were structurally characterized by NMR spectroscopy mult...

Evidence-Tiered Venomics of the BotG50 Toxic Fraction from Buthus tunetanus Reveals a Diversified Neurotoxin Repertoire

Scorpion venoms represent complex pharmacological arsenals whose complete molecular inventory remains incompletely defined, particularly for North African buthid species of high medical relevance. Buthus tunetanus is among the most clinically significant scorpion species across t...

Ownership structure and firm performance in G5 countries: a dynamic panel ARDL approach with a focus on employee shareholding

Purpose This study examines how institutional, concentrated and employee ownership structures impact the financial performance of publicly listed firms across G5 countries. It aims to provide a comprehensive understanding of how different ownership types influence firm performanc...

Assessment of the macroeconomic and environmental impacts of renewable energy investments using a SAM-based multiplier model: The case of Tunisia

Energy transition is a major challenge for developing nations, and reducing energy use and greenhouse gas emissions is crucial for a sustainable economy. This shift in Tunisia is accompanied by the development of renewable energy sources and the improvement of energy efficiency,...

Ultrasound-guided transverse abdominis plane versus ilioinguinal/iliohypogastric block for postoperative analgesia in pediatric inguinal surgery: a randomized comparative study

Ultrasound-guided ilioinguinal/iliohypogastric (IIIH) block and transverse abdominis plane (TAP) block are used for postoperative analgesia after pediatric inguinal surgery. The IIIH block is a targeted nerve block, whereas the TAP block is a fascial plane block that depends on l...

Supplier's origin and customer perceived value in inter-organizational relationships: the case of the Tunisian retailing sector

Purpose The aim of this article is to empirically study the relationship between supplier origin (SO) and key retailers’ perceived value (RPV) in their collaborative relationships with local suppliers, taking cultural dynamics into account. This theoretical question is examined f...

Exploring Barriers and Drivers to Energy Efficiency in the Tunisian Industrial Sector: A Qualitative Investigation

Energy efficiency (EE) has emerged as the paramount and cost-effective key strategy for achieving climate and energy objectives. Nonetheless, energy efficiency measures (EEMs) are frequently hindered by various barriers. Barriers, and to a lesser extent drivers, have been thoroug...

Gamma Irradiation Effects on Fatty Acid Profiles, Adhesion, Plasmid Stability, and Secreted Proteins in Shigella: In Silico Insights into Post-Irradiation Virulence

This study investigated the adaptive mechanisms of Shigella sonnei ATCC25931 in response to gamma irradiation stress (0.5 and 1 kGy), with a specific focus on the involvement of fatty acids (FAs) in membrane lipid composition remodeling, adherence, and extracellular proteins. The...

Multiphase Flow Simulation in Hydrocarbon Reservoir: Balancing Computational Efficiency and Prediction Accuracy

ABSTRACT High‑fidelity reservoir simulations remain indispensable for predicting multiphase flow in porous media, yet their computational cost impedes real‑time decision‑making. Recent advances have demonstrated that deep‑learning proxies—such as convolutional and recurrent neura...

The Role of Resilience in Relation to Depression, Anxiety, Stress, and Post-Traumatic Stress Symptoms Among Syrian Refugee Adolescents in Türkiye

Objectives: Mental health problems and post-traumatic stress symptoms are prevalent among adolescent refugees, yet little is known about the role of resilience in relation to these difficulties among Syrian adolescents. This study examined the unique contribution of resilience to...

Early Surgery in Crohn’s Disease: Clinical and Evolutionary Profile

Background: Crohn’s disease (CD) is a chronic condition with increasing prevalence, where early management is crucial for improving long-term prognosis. This study aimed to assess the rate of early surgery, identify associated factors, and compare the outcomes of patients undergo...

Less is more? Evaluating the role of radioiodine therapy in pediatric differentiated thyroid cancer management

Purpose: Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy in children and adolescents. Pediatric DTC often presents with extensive nodal disease or pulmonary metastases, yet disease-specific survival consistently exceeds 95-98%. This paradox challeng...

Beyond Diagnosis: Structural Stigma, Trauma, and Mental Health Among People Living with HIV in Tunisia: A Narrative Review

HIV-related stigma constitutes a critical structural determinant that adversely affects mental health and treatment outcomes among people living with HIV (PLWH) in Tunisia. Rooted in cultural conservatism, legal criminalization, and institutional discrimination, this stigma engen...