Tumor Hospital of Guangxi Medical University

MiPEP133 enhances anti-tumor immunity in nasopharyngeal carcinoma by activating CD8 + T cells

Activation of the tumor immune microenvironment (TIME) is crucial for controlling nasopharyngeal carcinoma (NPC) progression. This study aims to identify miPEP133 as novel therapeutic targets for NPC treatment. RNA-Seq was used to assess miPEP133’s effect on NPC cells and T-cell-...

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy is largely ineffective in most solid tumors, partially because of inadequate intratumoral trafficking. Bridging therapy, administered between leukapheresis and CAR‐T cell infusion, offers a distinct opportunity to control th...

Mast cell–derived SPP1 promotes colorectal cancer liver metastasis by suppressing BTG1-mediated JUN degradation

The role of mast cells in colorectal cancer (CRC) liver metastasis remains controversial. This study aimed to explore the effect of mast cells on the CRC liver metastasis and the underlying mechanism. The bulk-seq, scRNA-seq datasets and clinical samples were integrated to identi...