Tulane Medical Center

Interleukin-17A directly triggers Epstein-Barr virus lytic reactivation in latency I human B-cell models

ABSTRACT Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus implicated in inflammatory, malignant, and autoimmune diseases. Although EBV toggles between latent and lytic states, the host cues controlling this switch remain incompletely defined. Interleukin-17A (IL-17...

Workload and Perceived Burden From a National Survey of Surgeons

Importance Surgeon workload is substantial, but data characterizing perceived burden are scarce, limiting workforce planning, surgeon well-being, and patient safety. Objective To characterize surgeon workload and factors associated with perceived burden. Design, Setting, and Part...

CK2 targeting potentiates antineoplastic effects of dual HER2/EGFR inhibitor lapatinib and attenuates growth factor-induced epithelial-mesenchymal transition

CK2 is a pleiotropic, heterotetrameric kinase elevated in numerous cancers and, as such, has garnered much attention as a target for novel antineoplastic agents. Currently, silmitasertib, a selective CK2 inhibitor, has an orphan designation for medulloblastoma and neuroblastoma....