Trinity Health

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Live and learn: Student pharmacists' perceptions of a pharmacy resident led NAPLEX® prep bootcamp

Background Amid declining NAPLEX® pass rates, a resident-led, low-resource preparatory bootcamp was implemented to support fourth-year pharmacy students through flexible, student-centered sessions. Impact Students were asked to complete a pre-survey ( n = 26) and post-survey ( n...

Obstetric and thrombotic outcomes among pregnant patients with myeloproliferative neoplasms: a propensity score matched real-world analysis

Pregnancies complicated by BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are associated with increased maternal and thrombotic risk; however, large real-world comparative data remain limited. We performed a multicenter retrospective propensity score-matched cohort study...

Advancements on centelloside biosynthesis in tissue cultures of Centella asiatica (L.) Urban

Centella asiatica (L.) Urban is a medicinal herb widely valued for its bioactive triterpenoid saponins, collectively known as centellosides, which include asiaticoside (ASI), madecassoside (MAD), asiatic acid (ASA), and madecassic acid (MDA). These compounds exhibit diverse pharm...

Hypertension in Young Adults in Nigeria: A Review of Prevalence and Emerging Trends

Abstract Background Hypertension is increasingly being observed among young adults in low- and medium-income countries, including Nigeria. Although national estimates show a rising burden over the last three decades, the extent to which these trends affect younger populations rem...

Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways

Sporadic pancreatic neuroendocrine tumors (pNETs) with wild type MEN1 represent a major yet largely ignored subset whose biology and metastatic potential remain poorly understood. Because metastasis can occur despite low histologic grade and modest mutational burden, we hypothesi...

Epidemiology of Health-Related Social Needs Screening and Positivity in a Multistate Health System

Importance: Health systems increasingly screen for health-related social needs (HRSNs), which are modifiable social factors associated with health outcomes. However, screening selection biases and HRSN burdens are poorly characterized. Objective: To evaluate patient characteristi...