Trier University of Applied Sciences

Active Shielding of Glass Capillaries for the Compensation of Parasitic Effects in Transepithelial Electrical Resistance Measurements of Organoids

Abstract Capillary-based TEER measurements are affected by parasitic capacitances that distort the impedance spectrum and compromise reliable determination of barrier resistance of 3D cell structures, e.g. organoids. In this study, an actively shielded glass capillary concept is...

Psychotherapy remission prediction models show limited cross-clinic generalizability in routine outpatient care

Abstract Clinical prediction models for psychotherapy outcomes have the potential to assist therapists in planning a patient’s individual treatment, but their clinical utility depends on maintaining predictive performance across settings. We assessed prediction of post-treatment...

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has ev...

Entity Component System as a Relational Model: Archetypes, Component-Centric Relations, and Normal Forms

The Entity Component System (ECS) is a data-oriented software architectural pattern for the efficient organization of entities and associated components and is used in particular in performance-critical applications such as video games and real-time simulations.In the literature,...

Systematic Review of the Global Patterns and Determinants of International Student Mobility

ABSTRACT This systematic literature review synthesizes and analyses a corpus of 140 studies on the size and flows of international student mobility (ISM), as well as its determinants. The review confirms a consistent global increase in international students, albeit experienced d...

Estimation and Bias Adjustment of Regional Mortality Rates with Incomplete Information—The Case of German Federal States

Reliable regional mortality rates are crucial for public health monitoring and planning. However, their estimation is often complicated by data limitations, with data being published only in broad age groups or affected by systematic errors. This is particularly relevant in inter...

A probabilistic approach to shape derivatives

Abstract We introduce a novel mesh-free and direct method for computing the shape derivative in PDE-constrained shape optimization problems. Our approach is based on a probabilistic representation of the shape derivative and is applicable for second-order semilinear elliptic PDEs...

Nanoparticle Emissions of Ageing Diesel Cars with DPF—A First European PTI-like Field Study

This paper investigates nanoparticle emissions from older diesel passenger cars in four European countries outside of PTI (periodic technical inspection) testing facilities, using a methodology similar to that of the PTI. Per opportunistic sampling and voluntary testing, 618 dies...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...