Translational Research in Oncology

Acquired Resistance to the PRMT5 Inhibitor Confers Collateral Sensitivity to MEK Inhibition in MTAP-Null Non-Small Cell Lung Cancer

Abstract Protein arginine methyltransferase 5 (PRMT5) is a synthetic lethal target in methylthioadenosine phosphorylase-deleted (MTAP-null) cancers. Second-generation MTA-cooperative PRMT5 inhibitors preferentially target MTAP-null cells while largely sparing MTAP-wildtype (MTAP-...

AnticancerPotential of Camalexin-Derived Ru(II) Metallacycles

Abstract Camalexin, a primary indole-analogous phytoalexin from Arabidopsis thaliana and other crucifers, inhibits the proliferation of various cancer cells. In this contribution, the synthesis and characterization of camalexin-derived Ru(II) half-sandwich complexes are described...