Translational Genomics Research Institute

Association between handedness and Alzheimer's disease: Results from a large MindCrowd observational study

BackgroundHandedness is tied to the lateralization of brain functions and significantly affects cognitive function and brain activity. Alzheimer's disease (AD) is a progressive brain disorder that leads to declines in memory, thinking skills, and to behavioral changes, which also...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Portable Low-Field MRI of the Brain in Clinic and Community Settings

This cohort study evaluates portable, low-field magnetic resonance imaging (MRI) against conventional MRI in memory clinic and community cohorts.

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

ABSTRACT Sepsis‐induced pediatric acute lung injury (ALI) and pediatric acute respiratory distress syndrome (PARDS) are life‐threatening conditions with high mortality rates and no current cure. Most ALI/ARDS studies focus on adults, albeit the pediatric population has unique cha...

Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics

Abstract Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current diagnostic approaches rely on histology, which exhibits wide diagnostic variability and lacks clinically relevant molecular phenotyping. Here we leverag...