Traditional Chinese Medicine Hospital of Kunshan

Protective effects of icariin in atherosclerotic cardiovascular disease: mechanistic basis, post-ischemic protection and translational limitations

CONTEXT: Icariin (ICA), a prenylated flavonol glycoside from Epimedii Folium, has been investigated in experimental models relevant to atherosclerosis, myocardial infarction, and ischemic tissue injury. OBJECTIVES: This review evaluates experimental evidence on ICA in atheroscler...

IRP1 affects the long-term survival and function of iTregs by regulating ferroptosis and apoptosis

As an important classification of Tregs, iTregs play a critical role in inducing transplant immune tolerance. Iron metabolism is closely linked to iTreg function, and IRP1 serves as a central regulator of cellular iron homeostasis. However, the relationship between IRP1 and iTreg...

Hepatobiliary phase imaging in HCC: revisiting diagnostic algorithms and clinical utility of gadoxetic acid-enhanced MRI across international guidelines

Abstract Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide. In at-risk populations, noninvasive imaging diagnosis relies primarily on the vascular hallmarks of arterial phase hyperenhancement and washout appearance. However, these features...

Integrative Traditional Chinese Medicine Approaches for Plasma Cell Mastitis: Clinical Efficacy and Mechanistic Insights—A Narrative Review

Background Plasma cell mastitis (PCM) is a chronic nonlactational inflammatory breast disease characterized by recurrent inflammation, abscesses, sinus tracts, fibrosis, and high recurrence risk. Current treatments mainly target symptoms and complications but may not fully addres...

Role and diagnostic value of miR-3188 targeting OGT in regulating osteoblast function in delayed fracture healing of tibial fractures

This study investigated the role and mechanism of miR-3188 in delayed healing of tibial fractures, aiming to aid diagnosis and targeted intervention. A total of 172 patients with tibial fracture were enrolled and divided into normal fracture healing group (NFH, n = 82) and DFH (...

The genetic architecture of the CSF-contacting nucleus in mice and the screening of its key target via CSF pathway for mediating neuropathic pain

The cerebrospinal fluid (CSF)-contacting nucleus has been well characterized in rats and macaques but not yet precisely defined in mice. This study aims to provide a comprehensive description of the location, adjacent structures, cell morphology, spatial imaging, and genetic arch...