Townsville Hospital

Severe rhabdomyolysis and acute kidney injury associated with probable Legionella pneumophila infection: a case report

Abstract Background Legionella pneumophila infection is an uncommon but recognised association with severe rhabdomyolysis and acute kidney injury. We describe an atypical, predominantly extrapulmonary presentation complicated by several plausible causes of rhabdomyolysis and upda...

Evaluating Postoperative Radiotherapy Pathways for Head and Neck Cancer Patients in a Regional Hospital in Australia

ABSTRACT Introduction Timely initiation of postoperative radiotherapy (PORT) is critical in head and neck cancer, with delays exceeding 42 days associated with inferior outcomes. However, delays remain common, particularly in regional settings. This study aimed to evaluate target...

Beyond the Biomarkers: Gestation-Dependent Roles of sFLT-1 and PlGF in Human and Non-Human Mammalian Placental Development and Function

Placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFLT-1) are established biomarkers of placental dysfunction, but their functions extend beyond the maternal circulating ratio. This structured narrative review examines the FLT1–PlGF–vascular endothelial growt...

Corticosteroid use in children with community acquired sepsis: a multicentre prospective cohort study

Objectives Corticosteroids in paediatric sepsis have the potential to improve outcomes, yet there is little supporting evidence regarding efficacy, choice of agents, dose or timing of administration. We describe the patterns of corticosteroid use in children hospitalised with sus...

Co‐Design of a Theory‐Informed, Multicomponent, Intervention for Diagnostic Stewardship in a Major‐Referral Emergency Department: A Qualitative Descriptive Study

ABSTRACT Objective Low‐value diagnostic tests harm patients. Stewardship of tests can improve patient safety. Co‐design and behavioural change theories can enhance the effectiveness of diagnostic stewardship interventions. This study aimed to co‐design a theory‐informed diagnosti...

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

ABSTRACT Ductal carcinoma in situ (DCIS) is a non‐invasive precursor of invasive ductal carcinoma (IDC), yet the biological mechanisms underlying the transition from DCIS to IDC remain incompletely understood. Here, we integrate spatial transcriptomics, single‐cell RNA sequencing...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Clinically significant hypokalaemia and the utilisation of cardiac telemetry in hospitalised adults

Hypokalaemia is one of the most common electrolyte abnormalities in hospitalised patients, with moderate (2.5–3.0 mmol/L) to severe (< 2.5 mmol/L) deficiency associated with an increased risk of cardiac arrhythmias, prolonged hospitalisation, and inpatient mortality [1]. While cl...